Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807
Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807
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DOI：
10.3233/jad-122059
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发表时间：
2013-01-01
影响因子：
4
通讯作者：
Kolb, Hartmuth C.
中科院分区：
文献类型：
--
作者：
Chien, David T.;Bahri, Shadfar;Kolb, Hartmuth C.
过度磷酸化tau的聚集体(PHF-tau)，如神经原纤维缠结，与阿尔茨海默病的认知损害程度有关。我们已经开发了一种新型的PHF-tau靶向正电子发射断层成像显像剂[F-18]-T807，它可能用于阿尔茨海默病和其他牛磺酸的成像。在这里，我们描述了第一个使用[F-18]-T807的人脑图像。
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.