Comparative Analysis of the Retinal Microvasculature Visualized With Fluorescein Angiography and the Retinal Function Imager
Comparative Analysis of the Retinal Microvasculature Visualized With Fluorescein Angiography and the Retinal Function Imager
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DOI：
10.1016/j.ajo.2012.03.052
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发表时间：
2012-11-01
影响因子：
4.2
通讯作者：
Garg, Sunir J.
中科院分区：
文献类型：
--
作者：
Witkin, Andre J.;Alshareef, Rayan A.;Garg, Sunir J.
目的：比较静脉荧光素血管造影术(IVFA)和视网膜功能成像仪(RFI)对视网膜微血管的显示情况。设计：多中心、回顾性、观察性病例系列。方法：对7只正常眼和26只眼各种眼部疾病患者同时进行IVFA和RFI成像。比较IVFA和RFI图像对血管环、垂直侧支血管、中心凹无血管区(FAZ)大小和血管分支程度的显示能力。结果：RFI显示的血管环数目(1.3vs0.4只眼)和垂直侧支血管数目(4.42vs0.97只眼)均高于IVFA。平均而言，与IVFA相比，RFI的血管分支级别更高(5.2比4.6)。RFI能更清晰地显示中心凹无血管区(FAZ)，RFI测量的FAZ明显小于RFI(0.35vs0.75 mm(2))。结论：RFI是一种无创的视网膜成像设备，比IVFA更详细地显示血管环、垂直侧支血管、FAZ的面积和血管分支的顺序。该仪器可能有助于了解一些常见眼病以及正常眼的视网膜血管动态变化。《眼科杂志》2012；154：901-907。(C)2012年由Elsevier Inc.保留所有权利。)
PURPOSE: To assess the visualization of the retinal microvasculature with intravenous fluorescein angiography (IVFA) compared to the Retinal Function Imager (RFI).DESIGN: Multicenter, retrospective, observational case series.METHODS: Seven normal eyes and 26 eyes with various ocular diseases were imaged with both IVFA and the RFI. The ability to assess vessel loops, vertical collateral vessels, the size of the foveal avascular zone (FAZ), and degree of vessel branching were compared between IVFA and RFI images.RESULTS: The RFI visualized a greater number of vessel loops (1.3 vs 0.4 per eye) and vertical collateral vessels (4.42 vs 0.97 per eye) than IVFA. On average, higher order of vessel branching was seen with the RFI compared to IVFA (5.2 vs 4.6). The foveal avascular zone (FAZ) was more clearly delineated using the RFI and was significantly smaller when measured on RFI (0.35 vs 0.75 mm(2)).CONCLUSIONS: RFI, a noninvasive retinal imaging instrument, revealed vessel loops, vertical collateral vessels, the area of the FAZ, and order of vessel branching in greater detail than IVFA. This instrument may be helpful in understanding dynamic retinal vascular changes in a number of common ocular diseases, as well as in normal eyes. (Am J Ophthalmol 2012;154: 901-907. (C) 2012 by Elsevier Inc. All rights reserved.)