Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives.
Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives.
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DOI：
10.1038/sj.bjc.6603386
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发表时间：
2006-11-06
影响因子：
8.8
通讯作者：
Field, J K
中科院分区：
文献类型：
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作者：
Cassidy, A;Myles, J P;Duffy, S W;Liloglou, T;Field, J K
为了调查当一级亲属被诊断出患有肺癌时，早期患肺癌的鲜为人知的风险，1998年至2004年间，使用涵盖人口统计学和生活方式的标准化问卷对利物浦的579例发病病例和1157例人群对照进行了研究。一级亲属肺癌史与先证者的风险显著增加相关，其中两个人的癌症均在60岁之前被诊断（比值比（OR）=4.89; 95%置信区间（CI）：1.47-16.25）。无论发病年龄如何，在60岁以前患病的亲属患肺癌的风险也显著升高（OR=2.08; 95%CI：1.20-3.59）。这一发现与早发性肺癌风险中的遗传成分非常一致。
To investigate the little known risk of lung cancer at an early age when a first-degree relative has had such a diagnosis, 579 incident cases and 1157 population controls were studied in Liverpool between 1998 and 2004 using standardised questionnaires covering demography and lifestyle. A history of lung cancer in first-degree relatives was associated with a significantly increased risk in the proband where in both individuals the cancers were diagnosed before the age of 60 years (odds ratio (OR)=4.89; 95% confidence interval (CI): 1.47–16.25). A significantly elevated risk of lung cancer was also observed in association with a relative affected before the age of 60 years, regardless of age-at-onset of the disease (OR=2.08; 95% CI: 1.20–3.59). This finding is strongly consistent with a genetic component in early-onset lung cancer risk.