Reference values for the serum lipid profile of albino rats (Rattus norvegicus) of varied ages and sexes.
Reference values for the serum lipid profile of albino rats (Rattus norvegicus) of varied ages and sexes.
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DOI：
10.1007/s00580-011-1372-7
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Ihedioha, T. E.
中科院分区：
文献类型：
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作者：
Ihedioha, J. I.;Noel-Uneke, O. A.;Ihedioha, T. E.
Albino rats (Rattus norvegicus) are the most commonly used laboratory animals for studies on the effects of drugs, supplements, herbal extracts and diets on the serum lipid profile (SLP), yet there is no comprehensive set of reference values for the SLP of albino rats of varied ages and sexes in available literature. This study was designed to assay the SLP of albino rats of varied ages and sexes. A total of 480 Sprague Dawley albino rats were used for the study, composed of 240 females and 240 males. The age sets studied were rats of 4, 6, 8, 10, 12, 16, 20, 30, 40, and 50 weeks of age. For each age set, the SLP of 24 females and 24 males was assayed. Standard biochemical procedures were followed in the SLP assay after a 12-h overnight fast of the rats. Results showed that serum levels of total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and low density lipoprotein cholesterol (LDLC) significantly rose (p
