Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice.
Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice.
复制标题
膳食维生素 E 对二甲肼诱导的小鼠结肠肿瘤的影响。
作者：
M. Cook;P. McNamara
本研究探讨了饮食中维生素E的变化对二甲基肼诱导的小鼠结肠肿瘤发病率的影响。两组65只LACA小鼠每周28次皮下给药。注射二甲基肼两组管理的唯一差异是维生素E的饮食含量;一组接受10 mg/kg，另一组接受600 mg/kg。在这两组中，分别有42只和51只小鼠存活，并且在饮食中补充低维生素E的组中有更多的腺瘤，更多的多形性细胞学腺瘤和更多的浸润性癌。提示维生素E可能在饮食对结直肠癌发生的多因素作用中起一定作用。
This study investigates the effect of variations in dietary vitamin E on the incidence of dimethylhydrazine-induced colonic tumors in mice. Two groups of 65 LACA mice were given 28 weekly s.c. injections of dimethylhydrazine. The only difference in the management of the two groups was the dietary content of vitamin E; one group received 10 mg/kg, and the other group received 600 mg/kg. Of these two groups, 42 and 51 mice, respectively, survived, and there were significantly more adenomas, more adenomas with pleomorphic cytology, and more invasive carcinomas in the group receiving a low vitamin E supplement to their diet. It is suggested that vitamin E may have some part to play in the multifactorial effect of diet on colorectal carcinogenesis.