Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
复制标题
DOI：
10.1136/gutjnl-2018-316451
复制
发表时间：
2019-01-01
期刊：
影响因子：
24.5
通讯作者：
Gress, Thomas M.
中科院分区：
文献类型：
--
作者：
Neesse, Albrecht;Bauer, Christian Alexander;Gress, Thomas M.
胰腺导管腺癌（Pancreatic ductal adenocarcinoma，PDA）是一种侵袭性很强且难以治疗的肿瘤，PDA内的肿瘤微环境（tumor microenvironment，TME）是一种高度动态的微环境，可促进肿瘤的进展、转移灶的形成和耐药。近年来的深入研究揭示了TME的不同成分的令人难以置信的异质性和复杂性，包括癌症相关的成纤维细胞，免疫细胞，细胞外基质成分，肿瘤血管和神经。据推测，肿瘤上皮细胞和TME隔间之间的旁分泌相互作用可能会导致肿瘤促进或肿瘤抑制的后果。需要对这种复杂和动态的网络系统有更好的临床前理解，以便为患者开发更强大的治疗策略。近年来，科学活动和令人信服的发现数量几乎爆炸式增长。在这里，我们提供了在这一领域的最新研究结果的更新，并讨论了他们的基础科学家和临床医生的翻译和临床意义。
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote tumour progression, metastasis niche formation and therapeutic resistance. Intensive research of recent years has revealed an incredible heterogeneity and complexity of the different components of the TME, including cancer-associated fibroblasts, immune cells, extracellular matrix components, tumour vessels and nerves. It has been hypothesised that paracrine interactions between neoplastic epithelial cells and TME compartments may result in either tumour-promoting or tumour-restraining consequences. A better preclinical understanding of such complex and dynamic network systems is required to develop more powerful treatment strategies for patients. Scientific activity and the number of compelling findings has virtually exploded during recent years. Here, we provide an update of the most recent findings in this area and discuss their translational and clinical implications for basic scientists and clinicians alike.