3.0T MRI tractography of lumbar nerve roots in disc herniation
3.0T MRI tractography of lumbar nerve roots in disc herniation
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DOI：
10.1177/0284185113508179
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发表时间：
2014-10-01
期刊：
影响因子：
1.3
通讯作者：
Zhao Bin
中科院分区：
文献类型：
--
作者：
Li Chuanting;Wang Qingzheng;Zhao Bin
背景纤维追踪弥散张量成像（DTI）已在中枢神经系统的临床评价中得到应用，并已广泛用于白色物质束的成像。目的探讨腰椎间盘突出症患者行腰椎间盘神经根放射治疗的可行性，并评估L4、L5、L6、L7、L8、L9、L10、L11、L12、L13、L14、L15、L16、L17、L18、L19、材料与方法20例与后外侧或椎间孔椎间盘突出相关的单侧坐骨神经痛患者，20名健康志愿者参加了我们的研究。与轴位T2序列的解剖融合用于评估重建的相关性。对L4、L5和S1神经进行DTI和纤维束成像。结果纤维束成像能清晰显示腰骶神经根受压部位，并能显示腰骶神经根的ADC值。健康志愿者同水平左右侧神经根FA、ADC值差异无统计学意义（P>0.05）。受压脊神经根的FA值明显低于对侧神经根的FA值（P=0.0001）。受压侧神经根的ADC值明显高于对侧神经根（P=0.0002）。结论3T磁共振成像（MRI）DTI和FT对腰骶部神经的显示是可行的。在受压的L4、L5和S1神经中FA和ADC值有显著变化。
Background Diffusion tensor imaging (DTI) with fiber tracking (FT) has found clinical applications in the evaluation of the central nervous system and has been extensively used to image white matter tract. The feasibility of FT of the lumbar nerve roots in disc herniation is unclear.Purpose To demonstrate the feasibility of FT in the lumbar nerve roots, and to assess potential differences in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of L4, L5, and S1 nerves between healthy disc and disc herniation.Material and Methods Twenty patients with unilateral sciatica related to posterolateral or foraminal disc herniation and 20 healthy volunteers were enrolled in our study. Anatomical fusion with the axial T2 sequences was used to estimate the relevance of reconstructions. DTI with tractography of the L4, L5, and S1 nerves was performed. Mean FA and ADC values were calculated from tractography images.Results Lumbosacral root compression sites could be clearly identified on the tractography images. There was no significant difference in FA or ADC between left and right nerve roots at the same level (P>0.05) in healthy volunteers. The mean FA value of the compressed spinal nerve roots was significantly lower than that of FA of the contralateral nerve roots (P=0.0001). ADC was significantly higher in compressed nerve roots than that in the contralateral nerve root (P=0.0002).Conclusion 3T magnetic resonance imaging (MRI) DTI and FT of the lumbosacral region nerve is possible. There are significant changes in FA and ADC values in the compressed L4, L5, and S1 nerves.