Modulation of retinal transducin and phosphodiesterase activities by synthetic peptides of the phosphodiesterase gamma-subunit.
Modulation of retinal transducin and phosphodiesterase activities by synthetic peptides of the phosphodiesterase gamma-subunit.
复制标题
通过磷酸二酯酶γ亚基的合成肽调节视网膜转导蛋白和磷酸二酯酶活性。
DOI：
10.1016/0014-5793(87)80383-6
复制
发表时间：
1987
期刊：
影响因子：
3.5
通讯作者：
Takemoto,DJ
中科院分区：
文献类型：
--
作者：
Morrison,DF;Rider,MA;Takemoto,DJ
Synthetic peptides corresponding to various regions of the light‐activated guanosine 3′,5′‐cyclic monophosphate phosphodiesterase (PDE) γ‐subunit (PDEγ) from bovine retinal rod outer segments were synthesized and tested for their ability to inhibit PDE activity, and GTPase activity of transducin. One of these peptides, corresponding to PDEγ residues 31–45, inhibited PDE activity and GTPase activity in a dose‐dependent manner. The GTPase activity was inhibited by PDEγ‐3 non‐competitively. This region of the PDEγ subunit may be involved in the direct interaction of transducin and PDEαβ with PDEγ.
