Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogaster
Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogaster
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DOI：
10.1016/j.ibmb.2003.06.001
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发表时间：
2003-12-01
影响因子：
3.8
通讯作者：
Nelson, CA
中科院分区：
文献类型：
--
作者：
Riddiford, LM;Hiruma, K;Nelson, CA
这篇简短的评论总结了我们目前的知识蜕皮激素和保幼激素（JH）在烟草天蛾，天蛾和果蝇幼虫蜕皮和变态的转录因子的作用。我们发现了新的证据，EcR-A/USP-2和E75 A有助于蜕皮激素峰值后MHR 3的下调。此外，有提示性证据表明，MHR 4和betaFTZ-F1都可以调节多巴脱羧酶的表达，因为蜕皮类固醇滴度下降。我们总结了广泛的转录因子，通常出现在表皮中的最后一个幼虫龄期和指定蛹角质层的形成在变态蜕皮的JH的调节。不同Broad同种型的过早表达也显示引起前胸腺的过早变性以及在其存在期间阻止蜕皮类固醇释放。(C)2003 Elsevier Ltd.保留所有权利。
This short review summarizes our current knowledge about the role of transcription factors regulated by ecdysteroids and juvenile hormone (JH) in larval molting and metamorphosis in the tobacco hornworm, Manduca sexta, and Drosophila melanogaster. We show new evidence that EcR-A/USP-2 and E75A contribute to the down-regulation of MHR3 after the peak of ecdysteroid. Also, there is suggestive evidence that both MHR4 and betaFTZ-F1 may regulate the expression of dopa decarboxylase as the ecdysteroid titer declines. We summarize the regulation by JH of the Broad transcription factor that normally appears in the epidermis in the final larval instar and specifies pupal cuticle formation at the metamorphic molt. Premature expression of different Broad isoforms also is shown to cause precocious degeneration of the prothoracic glands as well as to prevent ecdysteroid release during its presence. (C) 2003 Elsevier Ltd. All rights reserved.