Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium.
Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium.
复制标题
通过胎粪胆汁酸分析揭示胆汁酸代谢的发育模式。
DOI：
10.1016/0016-5085(80)90666-6
复制
发表时间：
1980
期刊：
影响因子：
29.4
通讯作者：
K. Walter
中科院分区：
文献类型：
--
作者：
P. Back;K. Walter
通过分析胎粪中胆汁酸的模式，可以部分地研究胆汁酸的发育代谢。采用现代分析技术，已经发现除了人类的主要胆汁酸（胆酸、鹅脱氧胆酸、脱氧胆酸和石胆酸）之外，胎粪中还存在几种“非典型”胆汁酸。这些“非典型”胆汁酸不太可能来自母胎转移，因此它们可能反映了特殊的胎儿胆汁酸代谢。在类固醇骨架的位置1和6的羟基化是经常遇到的。这些羟基化，以及3β-羟基-Δ 5化合物和5α系列胆汁酸的出现，表明胎儿胆汁酸的合成与成人明显不同。这些观察结果与成人胆汁淤积性疾病中发现的不寻常胆汁酸的来源有关。在胆汁淤积性肝病的条件下，胎儿生物合成模式似乎会重新出现。
The developmental metabolism of bile acids can be partly studied by the analysis of bile acid patterns in meconium. Employing modern analytical techniques, it has been found that besides the main bile acids of humans (cholic, chenodeoxycholic, deoxycholic, and lithocholic acids) several “atypical” bile acids occur in meconium. It is unlikely that these “atypical” bile acids are derived from materno-fetal transfer, and they therefore probably reflect a special fetal bile acid metabolism. Hydroxylations at positions 1 and 6 of the steroid skeleton are regularly encountered. These hydroxylations, as well as the occurrence of 3β-hydroxy-Δ5compounds and of bile acids of the 5α series, suggest that fetal bile acid synthesis differs markedly from that of the adult. These observations are of interest in relation to the origin of unusual bile acids found in the cholestatic condition of the adult. It appears that a resurgence of the fetal biosynthetic patterns takes place under the conditions of cholestatic liver disease.