Invasive cancers detected after breast cancer screening yielded a negative result: Relationship of mammographic density to tumor prognostic factors
Invasive cancers detected after breast cancer screening yielded a negative result: Relationship of mammographic density to tumor prognostic factors
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DOI：
10.1148/radiol.2301020589
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发表时间：
2004-01-01
期刊：
影响因子：
19.7
通讯作者：
Helvie, MA
中科院分区：
文献类型：
--
作者：
Roubidoux, MA;Bailey, JE;Helvie, MA
目的：评估常见的乳腺肿瘤预后特征，包括雌激素受体（ER）状态、分级、大小和检测方法与乳腺x线摄影密度的关系。材料和方法：该研究纳入了121名在乳腺癌诊断前17个月内乳房x光检查和乳腺体检结果均为阴性的妇女。乳房x线摄影密度根据乳腺成像报告和数据系统模式I至4进行分类（其中1表示脂肪乳房，4表示致密乳房）。腋窝淋巴结状态和肿瘤组织学ER状态、组织学分级、大小、分期和检测方法（单独乳房x光检查、单独触诊检查或触诊和乳房x光检查同时进行）按密度分类进行分析，并通过方差分析检验不同类别间的统计学差异。结果：以下变量按密度分类差异有统计学意义（P < 0.05）：ER积极性(15 15肿瘤类别我乳房,32个类别2 41肿瘤的乳房,37个三级49肿瘤的乳房,和8个16在4级的乳房肿瘤的雌激素受体阳性),发生1级肿瘤(8、11、19日在类别1和四个肿瘤,类别2、3级,4级的乳房,分别是1级),意味着肿瘤大小(11.3,13.0,14.7,19.7毫米类别1,分类2、3级,4级的乳房,分别),单用乳房x光检查（单用乳房x光检查1类、2类、3类、4类乳腺分别有13例、31例、36例和4例肿瘤），I期肿瘤的发生（1类、2类、3类、4类乳腺分别有10例、25例、28例和5例肿瘤为1期）。结论：在乳腺肿瘤发现前17个月内临床和乳腺x线筛查结果阴性的女性，随后诊断出的肿瘤往往为ER阴性，致密组织型患者的级别较高，体积大于脂肪型患者。(c) rsna， 2004年。
PURPOSE: To evaluate common breast tumor prognostic characteristics, including estrogen receptor (ER) status, grade, size, and method of detection, in relationship to mammographic density.MATERIALS AND METHODS: The study involved 121 women who had negative results at both screening mammography and breast physical examination within 17 months before a diagnosis of breast cancer. Mammographic density was classified according to Breast Imaging Reporting and Data System patterns I through 4 (where 1 indicates a fatty breast and 4 indicates a dense breast). Axillary nodal status and tumor histologic ER status, histologic grade, size, stage, and method of detection (mammography alone, palpation alone, or both palpation and mammography) were analyzed by density category and tested for statistically significant differences across categories by using analysis of variance.RESULTS: Statistically significant differences (P < .05) by density category were found for the following variables: ER positivity (15 of 15 tumors in category I breasts, 32 of 41 tumors in category 2 breasts, 37 of 49 tumors in category 3 breasts, and eight of 16 tumors in category 4 breasts were ER positive), occurrence of grade 1 tumors (eight, 11, 19, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were grade 1), mean tumor size (11.3, 13.0, 14.7, and 19.7 mm for category 1, category 2, category 3, and category 4 breasts, respectively), detection with mammography alone (13, 31, 36, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were detected with mammography alone), and occurrence of stage I tumors (10, 25, 28, category 1, category 2, category 3, and category 4 breasts, ana five tumors in respectively, were stage 1).CONCLUSION: In women with negative results at clinical and mammographic screening within 17 months before breast tumor detection, subsequently diagnosed cancers tend to be ER negative, of higher grade, and larger in size in those with dense tissue patterns than in those with fat patterns. (C) RSNA, 2004.