Evidence that tolerance to cultured thyroid allografts is an active immunological process. Protection of third-party grafts bearing new antigens when associated with tolerogenic antigens.
Evidence that tolerance to cultured thyroid allografts is an active immunological process. Protection of third-party grafts bearing new antigens when associated with tolerogenic antigens.
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有证据表明对培养的甲状腺同种异体移植物的耐受是一个主动的免疫过程。
DOI：
10.1097/00007890-199204000-00036
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发表时间：
1992
期刊：
影响因子：
6.2
通讯作者：
Ammons,TJ
中科院分区：
文献类型：
--
作者：
LaRosa,FG;Smilek,D;Talmage,DW;Lafferty,KJ;Bauling,P;Ammons,TJ
我们研究了长期接受培养的甲状腺同种异体移植物的耐受现象。将同种异体小鼠甲状腺在高压氧或酸性条件下培养，然后移植到C57 BL/6受体的肾包膜下。供体与受体的差异仅在于次要抗原，仅在于主要组织相容性复合物抗原，或两者兼而有之。在第一次培养移植物后35-77周，受体在对侧肾包膜下接受两个培养移植物，并用供体脾细胞（SC）免疫。在第二次移植后5周，我们观察到，虽然第二次移植物携带新的抗原单独被排斥，第二次移植物携带新的抗原与第一次移植物中的抗原相关联的显着保护。
We studied the tolerance phenomenon that develops in long-term recipients of cultured thyroid allografts. Allogeneic mouse thyroids were cultured under hyperbaric oxygen or acidic conditions and then transplanted beneath the kidney capsule of C57BL/6 recipients. Donors differed from the recipients in minor antigens alone, major histocompatibility complex antigens alone, or both. At 35–77 weeks after the first cultured graft, recipients received two more cultured grafts under the capsule of the opposite kidney and were immunized with donor spleen cells (SC). At 5 weeks after the second transplantation, we observed that whereas second grafts carrying new antigens alone were rejected, second grafts carrying new antigens in association with antigens in the first graft were significantly protected.