Disturbed striatoprefrontal mediated visual behaviour in moderate to severe parkinsonian patients
Disturbed striatoprefrontal mediated visual behaviour in moderate to severe parkinsonian patients
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DOI：
10.1136/jnnp.63.3.296
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发表时间：
1997-09-01
影响因子：
11
通讯作者：
DeRidder, K
中科院分区：
文献类型：
--
作者：
Crevits, L;DeRidder, K
Objective-To study visual spatial and visual memory functions in moderate to severe parkinsonian patients.Methods - Visual antisaccades（AS）and remembered saccades（RS）were examined in 30 patients with moderate to severe Parkinson disease and in 44 age matched control.与目标相反方向的扫视。RS是扫视对一个目标，不再visible.Results -帕金森氏病患者有严重的困难，在抑制反射扫视（“视觉抓取”）或他们没有扫视（“视觉运动不能”）的记忆位置。记住的扫视往往是错误的directed.Conclusions -这些类型的错误点功能障碍的纹状体前额叶回路。结果与文献中的结果（大多数是正常的）的差异可以解释为我们患者的晚期。这可能对应于对左旋多巴无反应或非多巴胺能病变的发展。
Objectives - To study visuospatial and visual memory functions in moderate to severe parkinsonian patients.Methods - Visual antisaccades (AS) and remembered saccades (RS) were examined in 30 patients with moderate to severe Parkinson's disease and in 44 age matched controls. AS are saccades in the direction opposite to the target. RS are saccades towards the remembered position of a target that is no longer visible.Results - Patients with Parkinson's disease had serious difficulties in suppressing a reflex saccade (''visual grasping'') or they made no saccade at all (''visual akinesia''). The remembered saccade was often wrongly directed.Conclusions - These types of errors point to a dysfunction in the striatoprefrontal loop. The discrepancy of the results with those in the literature, which are mostly normal, could be explained by the more advanced stage of our patients. This might correspond to the development of unresponsiveness to levodopa or of nondopaminergic lesions.