Omega-3 Fatty Acids for Neuropathic Pain Case Series
Omega-3 Fatty Acids for Neuropathic Pain Case Series
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DOI：
10.1097/ajp.0b013e3181bb8533
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发表时间：
2010-02-01
影响因子：
2.9
通讯作者：
Hum, Annie
中科院分区：
文献类型：
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作者：
Ko, Gordon D.;Nowacki, Nathaniel Benjamin;Hum, Annie
目的：本病例系列研究的目的是调查和报告对omega-3脂肪酸治疗有反应的神经性疼痛患者。5名患有不同基础诊断（包括颈神经根病、胸廓出口综合征、纤维肌痛、腕管综合征、烧伤）的患者接受了高剂量口服欧米茄3鱼油（EPA-DHA为2400 - 7200 mg/天）治疗。治疗前和治疗后获得结果指标。这些包括经验证的调查（简式McGill疼痛问卷，DN4神经性疼痛量表，疼痛检测问卷），客观临床工具（Jamar握力。Lafayette测力法，压痛点测痛法）和EMG神经传导研究。结果：这些患者在治疗开始后19个月内具有临床显著的疼痛减轻，主观和客观结果测量LIP记录的功能改善。没有严重的不良反应reported.Conclusions：这是有史以来第一次报道的病例系列表明，ω-3脂肪酸可能是有益的神经性疼痛患者的管理。在更具体的神经性疼痛人群中进行随机对照试验的进一步研究将是必要的。
Objective: The aim of this case series Study was to investigate and report on patients with neuropathic pain who responded to treatment with omega-3 fatty acids.Methods: Methods: Five patients with different underlying diagnoses including cervical radiculopathy, thoracic outlet syndrome, fibromyalgia, carpal tunnel syndrome, burn injury were treated with high oral doses of omega 3 fish oil (varying from 24007200 mg/day of EPA-DHA). Outcome measures were obtained pretreatment and posttreatment. These included validated Surveys (short-form McGill Pain questionnaire, DN4 neuropathic pain scale, Pain Detect Questionnaire), objective clinical tools (Jamar grip strength. Lafayette dynamometry, tender point algometry) and EMG Nerve Conduction studies.Results: These patients had clinically significant pain reduction, improved function as documented with both Subjective and objective outcome measures LIP to as Much as 19 months after treatment initiation. No serious adverse effects were reported.Conclusions: This first-ever reported case series suggests that omega-3 fatty acids may be of benefit in the management of patients with neuropathic pain. Further investigations with randomized controlled trials in a more specific neuropathic pain population would be warranted.