Virulence determinants of pandemic influenza viruses
Virulence determinants of pandemic influenza viruses
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DOI：
10.1172/jci44947
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发表时间：
2011-01-01
影响因子：
15.9
通讯作者：
Garcia-Sastre, Adolfo
中科院分区：
文献类型：
--
作者：
Tscherne, Donna M.;Garcia-Sastre, Adolfo
甲型流感病毒会导致周期性的季节性流行和偶尔的全球大流行，发病率和死亡率都会达到毁灭性的水平甲型流感病毒适应各种宿主并经历重新分类事件的能力确保了不断产生致病性、传播性和大流行潜力不可预测的新毒株目前，推动大流行性流感出现的因素组合尚不清楚，因此无法预测未来爆发的细节甲型流感病毒毒力决定因素的识别和表征可能提供对致病性的基因特征的洞察，以及对引起大流行的因素的更彻底的理解
Influenza A viruses cause recurrent, seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality The ability of influenza A viruses to adapt to various hosts and undergo reassortment events ensures constant generation of new strains with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential Currently, the combination of factors that drives the emergence of pandemic influenza is unclear, making it impossible to foresee the details of a future outbreak Identification and characterization of influenza A virus virulence determinants may provide insight into genotypic signatures of pathogenicity as well as a more thorough understanding of the factors that give rise to pandemics