Decreased static and increased dynamic global signal topography in major depressive disorder
Decreased static and increased dynamic global signal topography in major depressive disorder
复制标题
重度抑郁症中静态全局信号拓扑减少和动态全局信号拓扑增加
DOI：
10.1016/j.pnpbp.2019.109665
复制
发表时间：
2019-08-30
影响因子：
5.6
通讯作者：
Chen, Huafu
中科院分区：
文献类型：
--
作者：
Han, Shaoqiang;Wang, Xiao;Chen, Huafu
重度抑郁症（MDD）与大规模大脑网络之间的不平衡通信有关。然而，MDD大规模协调性改变的细节仍然未知。探讨MDD中大规模功能组织的变化。我们使用静态和动态全局信号（GS）地形，这是数据驱动的方法来探索MDD中全局和局部神经元活动之间的变化关系。本研究招募了63名重度抑郁症患者和63名健康对照（hc）。MDD患者在双侧海马旁回和海马回的静态GS地形下降。与此同时，MDD患者在右侧腹内侧前额叶皮层动态GS地形变异性增加。这一结果可能反映了重度抑郁症患者全脑功能一致性的下降和不稳定。MDD患者右侧海马旁回静态GS地形下降与精神运动迟缓有关。我们的研究结果表明，改变的静态和动态GS地形可以为MDD的生理机制提供不同的证据。
Major depressive disorder (MDD) has been linked to imbalanced communication among large-scale brain networks. However, the details of altered large-scale coordination of MDD remains unknown. To explore the altered large-scale functional organization in MDD. We used static and dynamic global signal (GS) topography, which are data-driven methods to explore altered relationship between global and local neuronal activities in MDD. Sixty three MDD patients and matched 63 healthy controls (HCs) were recruited in current study. Patients with MDD presented decreased static GS topography in bilateral parahippocampal gyrus and hippocampus gyrus. Meanwhile, patients with MDD presented increased variability of dynamic GS topography in the right ventromedial prefrontal cortex. This result may reflect the decreased and unstable whole brain functional coherence in MDD. The decreased static GS topography in the right parahippocampal gyrus was correlated with psychomotor retardation in patients with MDD. Our results presented that the altered static and dynamic GS topography can provide distinct evidence on the physiological mechanisms of MDD.