Learning to cope with biting flies: Rapid NMDA-mediated acquisition of conditioned analgesia
Learning to cope with biting flies: Rapid NMDA-mediated acquisition of conditioned analgesia
复制标题
DOI：
10.1037/0735-7044.113.1.126
复制
发表时间：
1999-02-01
影响因子：
1.9
通讯作者：
Ossenkopp, KP
中科院分区：
文献类型：
--
作者：
Kavaliers, M;Colwell, DD;Ossenkopp, KP
暴露于完整的叮咬苍蝇（稳定的苍蝇）30分钟诱导阿片类药物介导的镇痛在由幼稚的雄性鹿小鼠，而暴露于改变叮咬苍蝇的叮咬口器被删除或nonbiting苍蝇没有显着的影响。然而，小鼠先前暴露于完整的稳定苍蝇30分钟时，表现出显着的镇痛暴露24-168小时后，稳定苍蝇的叮咬部分被删除，但不咬家蝇。在暴露于完整苍蝇之前，将特异性N-甲基-D-天冬氨酸（NMDA）拮抗剂NPC 12626给予未经处理的小鼠，尽管没有显著降低镇痛反应，但阻断了随后的条件性镇痛。纳洛酮，它阻止了完整的叮咬苍蝇诱导的镇痛，没有改变收购的条件性镇痛反应改变稳定的苍蝇。这证明了NMDA介导的对自然厌恶刺激的条件镇痛的获得。
A 30-min exposure to intact biting flies (stable flies) induced an opioid-mediated analgesia in By-naive male deer mice, whereas exposure to either altered biting flies whose biting mouthparts were removed or nonbiting house flies had no significant effects. However, mice that were previously exposed to intact stable flies for 30 min exhibited significant analgesia when exposed 24-168 hr later to stable flies whose biting parts were removed, but not to nonbiting house flies. Administration of the specific N-methyl-D-aspartate (NMDA) antagonist NPC 12626 to By-naive mice before exposure to intact flies, although not significantly reducing the analgesic response, blocked the subsequent conditioned analgesia. Naloxone, which blocked the intact biting fly-induced analgesia, did not alter the acquisition of the conditioned analgesic response to the altered stable flies. This demonstrates an NMDA-mediated acquisition of conditioned analgesia to a natural aversive stimulus.