Conformational properties and folding analysis of a series of seven oligoamide foldamers
Conformational properties and folding analysis of a series of seven oligoamide foldamers
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DOI：
10.1039/c5ce02458g
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发表时间：
2016-01-01
期刊：
影响因子：
3.1
通讯作者：
Nissinen, Maija
中科院分区：
文献类型：
--
作者：
Suhonen, Aku;Kortelainen, Minna;Nissinen, Maija
分析了一系列 7 个低聚酰胺折叠体的 33 种晶体结构（11 种非溶剂化物和 22 种溶剂化物）。晶体结构表明，尽管存在结构和环境差异，但折叠体系列仅偏好两种一般构象，即原螺旋@构象和S形S构象。两种构象还具有优选的晶体堆积图案和溶剂化物形成倾向。人们发现氢键是构象偏好中最决定性的因素，但空间性质、外围取代基的类型以及溶剂和芳香族相互作用也被发现对构象细节和晶体形式有影响。
33 crystal structures (11 unsolvated and 22 solvates) of a series of seven oligoamide foldamers were analysed. The crystal structures revealed that despite the structural and environmental differences the series of foldamers prefer only two general conformations, a protohelical @-conformation and a sigmoidal S-conformation. Both conformations also have preferred crystal packing motifs and solvate forming tendencies. Hydrogen bonding was found to be the most decisive factor in conformational preference, but steric properties, the type of the peripheral substituents, as well as solvent and aromatic interactions were also found to have an effect on the conformational details and crystal form.