The Swedish Twin Registry in the third millennium
The Swedish Twin Registry in the third millennium
复制标题
DOI：
10.1375/twin.5.5.427
复制
发表时间：
2002-10-01
期刊：
影响因子：
--
通讯作者：
Svedberg, P
中科院分区：
文献类型：
--
作者：
Pedersen, NL;Lichtenstein, P;Svedberg, P
自20世纪50年代末首次建立瑞典双胞胎登记处以来，该登记处一直在研究吸烟和饮酒对癌症和心血管疾病的重要性，并多次进行扩展和更新。同样，重点也扩大到了最常见的复杂疾病。数据库的内容进行了描述，正在进行的项目登记的基础上进行了总结，我们回顾了一些主要的研究结果，对老化，癌症和心血管疾病，已经从注册表。正在进行的努力和未来的计划的STR进行了讨论。除此之外，我们计划进行血液采集和基因分型，以研究复杂疾病的遗传基础，首次接触1958年以后出生的人群，并深入研究选定的疾病，如帕金森病和慢性疲劳综合征。
Since the Swedish Twin Registry was first established in the late 1950s to study the importance of smoking and alcohol consumption on cancer and cardiovascular diseases, it has been expanded and updated on several occasions. The focus has similarly broadened to most common complex diseases. The content of the database is described, ongoing projects based on the registry are summarized, and we review some of the principal findings on aging, cancer and cardiovascular disease that have come from the registry. Ongoing efforts and future plans for the STR are discussed. Among others, we plan blood collection and genotyping to study the genetic bases of complex diseases, a first contact ever with the cohorts born after 1958, and in-depth studies of selected diseases, such as Parkinson's disease and chronic fatigue syndrome.