Immunohistochemical Detection of Fibroblast Growth Factor Receptor 3 in Human Breast Cancer: Correlation with Clinicopathological/Molecular Parameters and Prognosis
Immunohistochemical Detection of Fibroblast Growth Factor Receptor 3 in Human Breast Cancer: Correlation with Clinicopathological/Molecular Parameters and Prognosis
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DOI：
10.1159/000314346
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发表时间：
2010-01-01
期刊：
影响因子：
5
通讯作者：
Ueda, Yoshihiko
中科院分区：
文献类型：
--
作者：
Kuroso, Kazuko;Imai, Yasuo;Ueda, Yoshihiko
目的：据报道，调节胚胎生长和发育的成纤维细胞生长因子受体 3 (FGFR3) 可能在某些恶性肿瘤中充当癌蛋白。我们的目的是研究 FGFR3 表达在浸润性乳腺癌中的生物学意义。方法：通过免疫组织化学方法研究 50 例浸润性乳腺癌标本中 FGFR3 的表达。评估了 FGFR3 表达与临床病理/分子参数或预后之间的关联。结果：在正常乳腺导管和小叶的肌上皮细胞中观察到较弱的 FGFR3 表达，但在导管上皮细胞中未观察到。 50例乳腺癌细胞中有19例（38.0%）观察到FGFR3表达（9例弱阳性，10例强阳性）。 10例强阳性病例中，除细胞质和细胞膜外，还有3例出现核染色。 5例强阳性病例中，在非肿瘤性导管上皮细胞或导管乳头状瘤病中进一步检测到FGFR3。 FGFR3 表达与特定临床病理/分子参数之间没有观察到显着相关性。相比之下，我们发现 FGFR3 表达与我们队列中的总体生存率显着相关。结论：未发现浸润性乳腺癌中的 FGFR3 表达与特定的临床病理/分子参数显着相关，但可能作为不良预后的候选标志物。版权所有 (C) 2010 S. Karger AG，巴塞尔
Objective: Reportedly, fibroblast growth factor receptor 3 (FGFR3) that regulates embryonic growth and development may function as an oncoprotein in certain malignancies. We aimed to investigate the biological significance of FGFR3 expression in invasive breast cancer. Methods: FGFR3 expression was investigated in 50 invasive breast cancer specimens by immunohistochemistry. The association between FGFR3 expression and clinicopathological/molecular parameters or prognosis was evaluated. Results: Weak FGFR3 expression was observed in myoepithelial cells, but not in duct epithelial cells, of the normal mammary ducts and lobules. FGFR3 expression in breast cancer cells was observed in 19 of 50 (38.0%) cases (9 weak positive and 10 strong positive). Besides the cytoplasm and cell membrane, nuclear staining was observed in 3 of 10 strong-positive cases. FGFR3 was further detected in non-neoplastic duct epithelial cells or duct papillomatosis in 5 strong-positive cases. No significant correlation was observed between FGFR3 expression and specific clinicopathological/molecular parameters. In contrast, FGFR3 expression was found to be significantly associated with overall survival in our cohort. Conclusions: FGFR3 expression in invasive breast cancer was not found to be significantly associated with specific clinicopathological/molecular parameters, but might be used as a candidate marker for a poor prognosis. Copyright (C) 2010 S. Karger AG, Basel