The influence of gestational diabetes mellitus (GDM) and gestational hypertension (GH) on placental morphological changes.
The influence of gestational diabetes mellitus (GDM) and gestational hypertension (GH) on placental morphological changes.
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妊娠糖尿病（GDM）和妊娠高血压（GH）对胎盘形态变化的影响。
DOI：
10.47162/rjme.61.2.07
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发表时间：
2020-04
期刊：
影响因子：
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通讯作者：
Voicu NL
中科院分区：
文献类型：
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作者：
Istrate-Ofiţeru AM;Berceanu C;Berceanu S;Busuioc CJ;Roşu GC;Diţescu D;Grosu F;Voicu NL
妊娠期糖尿病（GDM）和妊娠期高血压（GH）是与妊娠相关的一些最常见的医疗条件。这些可能与胎盘形态病理学变化相关，并隐含地影响良好的胎儿发育。母亲的年龄和体重与胎儿的年龄和体重成正比，但也与组织结构和胎盘血管化有关。与GDM和GH相关的胎盘外观显示了宏观特征，如钙化、纤维蛋白沉积和胎盘梗死，但最相关的病理学特征是显微镜特征，通过经典染色技术突出显示：苏木精-伊红（HE）、过碘酸-希夫（PAS）-苏木精和马森三色（MT），还可通过免疫组织化学技术，借助抗分化簇34（CD 34）抗体标记胎盘末端绒毛结构中的首都内皮，因此我们能够根据相关的医学病理学发现的显微镜变化表现为绒毛内和绒毛外纤维蛋白沉积、由各种原因（如血栓形成）引起的血管抑制引起的大面积胎盘梗死以及胎盘钙化。所有这些宏观和微观形态病理学变化，以及母亲和新生儿的临床数据，我们已经证明它们是相互关联的，并且它们可以根据病理学、GH或GDM而变化。
Gestational diabetes mellitus (GDM) and gestational hypertension (GH) are some of the most common medical conditions associated with pregnancy. These can be correlated with placental morphopathological changes and implicitly can influence good fetal development. The age and weight of the mother can be correlated directly proportionally with those of the fetus but also with histoarchitecture and placental vascularization. The placental appearance associated with GDM and GH reveals macroscopic features, such as calcifications, fibrin deposits and placental infarcts, but the most relevant pathological features are the microscopic ones, highlighted by the classical staining techniques: Hematoxylin–Eosin (HE), Periodic Acid–Schiff (PAS)–Hematoxylin and Masson’s trichrome (MT), but also by immunohistochemical technique with the help of the anti-cluster of differentiation 34 (CD34) antibody that labeled the capital endothelium in the structure of the placental terminal villi and thus we were able to quantify the vascular density according to the associated medical pathology. The microscopic changes identified were represented by intravillous and extravillous fibrin depositions, massive placental infarctions caused by vascular suppression due to various causes, such as thrombosis, but also placental calcifications. All these macroscopic and microscopic morphopathological changes, together with the clinical data of the mother and the newborn, we have demonstrated that they are interconnected and that they can vary depending on the pathology, GH or GDM.