Chronic Hepatitis B and Hepatocellular Carcinoma
Chronic Hepatitis B and Hepatocellular Carcinoma
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DOI：
10.1016/j.cld.2010.05.009
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发表时间：
2010-08-01
影响因子：
5.1
通讯作者：
Tong, Myron J.
中科院分区：
文献类型：
--
作者：
McClune, Amy C.;Tong, Myron J.
肝细胞癌（HOC）是世界上第五大最常见的癌症，也是癌症相关死亡的第三大原因。超过80%的HOC病例来自亚洲和非洲大陆，超过50%的病例来自中国大陆。大约有3.5亿到4亿人慢性感染乙型肝炎病毒（HBV），这种病毒是全球最常见的HOC病因。据估计，全世界50%以上的肝癌可归因于HBV，高达89%的HBV相关HCC发生在发展中国家。最近，一些西方国家（包括法国、澳大利亚和美国）报道了HOC发病率增加的趋势。
Hepatocellular carcinoma (HOC) is the fifth most common cancer in the world and the third leading cause of cancer-related deaths. More than 80% of HOC cases are from the Asian and African continents, and more than 50% of cases are from mainland China. Approximately 350 million to 400 million persons are chronically infected with hepatitis B virus (HBV), and this virus is the most common cause of HOC worldwide. It is estimated that more than 50% of liver cancers worldwide are attributable to HBV and up to 89% of HBV-related HCC are from developing countries. Recently, increasing trends in HOC incidence have been reported from several Western countries, including France, Australia, and the United States.