Small cell lung cancer (SCLC) incidence and trends vary by gender, geography, age, and subcategory based on population and hospital cancer registries in Hebei, China (2008-2017)
Small cell lung cancer (SCLC) incidence and trends vary by gender, geography, age, and subcategory based on population and hospital cancer registries in Hebei, China (2008-2017)
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DOI：
10.1111/1759-7714.13412
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发表时间：
2020-06-26
期刊：
影响因子：
2.9
通讯作者：
He, Yutong
中科院分区：
文献类型：
--
作者：
Li, Daojuan;Xu, Xiaoli;He, Yutong
背景肺癌是世界范围内发病率和死亡率最高的疾病。小细胞肺癌(SCLC)已被确定为最致命的肺部恶性肿瘤。以往很少有研究分析中国地区小细胞肺癌的流行病学特征。本研究分析了小细胞肺癌的流行病学特征，旨在为河北省小细胞肺癌的防治工作提供参考。方法利用河北省2008~2017年人口和医院肿瘤登记资料，分析小细胞肺癌的流行病学特征。结果以人群和医院为基础的小细胞肺癌患者所占比例均呈明显上升趋势。此外，根据人口和以医院为基础的病例，男性的比例高于女性。以医院为基础的小细胞肺癌病例以县为单位的比例高于城市，而以人口为基础的市县之间没有明显的地区差异。人口和以医院为基础的小细胞肺癌病例的比例随着年龄的增长而持续下降。小细胞肺癌亚类的人群分布和医院分布有差异。结论近年来，以人群和医院为基础的小细胞肺癌病例比例显著增加，尤其是男性和55岁以上的患者。因此，迫切需要对小细胞肺癌的发病机制和预防进行研究。
Background Lung cancer is the leading cause of morbidity and mortality worldwide. Small cell lung cancer (SCLC) has been determined to be the most lethal lung malignancy. Few studies have previously analyzed the epidemiological characteristics of SCLC in China. This study analyzed the epidemiological characteristics of SCLC aiming to provide a reference for the prevention of SCLC in Hebei Province. Methods The epidemiological characteristics of SCLC using lung cancer data based on population and hospital cancer registries in Hebei Province between 2008 and 2017 were analyzed. Results The proportion of both population- and hospital-based SCLC cases displayed a significant increasing trend. Moreover, the proportion of males was higher than that for female based on population- and hospital-based cases. The proportion of hospital-based SCLC cases in counties was higher than that in cities, whereas there were no significant regional differences between cities and counties based on population. The proportion of both population- and hospital-based SCLC cases decreased consistently with increasing age. There was a difference between population- and hospital-based distribution of subcategories of SCLC. Conclusions Significant increases in the proportion of both population- and hospital-based SCLC cases over recent years, particularly in males and in patients aged over 55 years, were observed. Research on the pathogenesis of SCLC in these patients and prevention is urgently required.