Secretion of DJ-1 into the serum of patients with Parkinson's disease
Secretion of DJ-1 into the serum of patients with Parkinson's disease
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DOI：
10.1016/j.neulet.2007.11.027
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发表时间：
2008-01-24
影响因子：
2.5
通讯作者：
Ariga, Hiroyoshi
中科院分区：
文献类型：
--
作者：
Maita, Chinatsu;Tsuji, Sachiko;Ariga, Hiroyoshi
DJ-1最初被我们鉴定为一种新的癌基因，后来被发现是家族性帕金森病PARK 7的致病基因。DJ-1在转录调节和氧化应激功能中起作用，并且其功能的丧失被认为与家族性和散发性形式的帕金森病（PD）的发病年龄、进展模式和临床严重程度相关。DJ-1位于细胞质和细胞核中，据报道它会分泌到乳腺癌、黑色素瘤、家族性淀粉样多发性神经病和中风患者的血清或血浆中。在本研究中，通过使用DJ-1 ELISA试剂盒检测分泌到健康对照和散发性PD患者血清中的DJ-1水平，并测量血清中的氧化应激水平。结果表明，DJ-1在正常人和PD患者血清中均有表达。两组间分泌的DJ-1水平无显著差异，未发现分泌的DJ-1水平与年龄、PD临床严重程度和氧化应激水平的相关性。（C）2007 Elsevier爱尔兰Ltd.版权所有。
DJ-1 was initially identified by us as a novel oncogene and has later been found to be a causative gene for familial Parkinson's disease PARK7. DJ-1 plays role in transcriptional regulation and in oxidative stress function, and loss of its function is thought to be related to onset age, mode of progression and clinical severity of both familial and sporadic forms of Parkinson's disease (PD). DJ-1 is localized both in the cytoplasm and nucleus, and it has been reported to be secreted into the serum or plasma of patients with breast cancer, melanoma, familial amyloidotic polyneuropathy and stroke. In this study, levels of DJ-1 secreted into the serum of healthy controls and patients with sporadic PD were examined by using a DJ-1 ELISA kit, and the level of oxidative stress in the serum was also measured. The results showed that DJ-1 was secreted into the serum of both healthy controls and PD patients. There was no significant difference between the levels of secreted DJ-1 in two groups, and correlations of levels of secreted DJ-1 with age, clinical severity of PD and level of oxidative stress were not found. (C) 2007 Elsevier Ireland Ltd. All rights reserved.