Autoimmune sensorineural hearing loss: A human temporal bone study
Autoimmune sensorineural hearing loss: A human temporal bone study
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DOI：
10.1016/s0196-0709(98)90063-1
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发表时间：
1998-01-01
影响因子：
2.5
通讯作者：
Paparella, MM
中科院分区：
文献类型：
--
作者：
Hoistad, DL;Schachern, PA;Paparella, MM
目的：描述临床病史提示自身免疫性感音神经性听力损失（SNHL）的患者颞骨的组织病理学结果。材料和方法：对有溃疡性结肠炎、白血病和SNHL病史的患者颞骨进行光镜检查。结果：组织病理学表现包括：(1)所有耳蜗转道缺失或缺失Corti器官；(2)螺旋神经节细胞减少，淋巴细胞浸润；(3)螺旋日珥部分缺失；(4)耳蜗基部、中部和顶端、囊体和耳蜗室有内淋巴积液；(5)耳蜗基底转、后半规管和耳蜗耳管的鼓膜纤维化和成骨；(6)前庭导水管及内淋巴囊纤维化；(7)淋巴细胞分布于内淋巴囊、囊周区、耳蜗下静脉和罗森塔尔管。结论：该溃疡性结肠炎、感音神经性听力损失和前庭症状患者颞骨的组织病理学结果与先前报道的自身免疫动物研究结果非常相似，提示自身免疫性SNHL的可能性。版权所有(C) 1998由W.B. Saunders公司。
Purpose: To describe histopathologic findings in temporal bones of a patient whose clinical history suggests a sensorineural hearing loss (SNHL) of autoimmune origin.Materials and Methods: Temporal bones from a patient with a history of ulcerative colitis, leukemia, and SNHL were examined by light microscopy.Results: Histopathologic findings included: (1) organs of Corti missing or absent in all cochlear turns; (2) cells decreased in spiral ganglia, and lymphocytic infiltration; (3) absence of portions of the spiral prominence; (4) endolymphatic hydrops in basal, middle, and apical cochlear turns and in the saccule and utricle; (5) fibrosis and osteoneogenesis of a scala tympani of the basal turn of the cochlea, the posterior semicircular canal, and the canal of Cotugno; (6) fibrosis of the vestibular aqueduct and endolymphatic sac; and (7) lymphocytes in the endolymphatic sac, perisaccular area, inferior cochlear vein, and Rosenthal's canal.Conclusion: Histopathologic findings in the temporal bones of this patient with ulcerative colitis, sensorineural hearing loss, and vestibular symptoms closely parallel those in a previously reported animal study of autoimmunity and suggest the possibility of a SNHL of autoimmune origin. Copyright (C) 1998 by W.B. Saunders Company.