Constrictive structural elements in human cerebral arteries following aneurysmal subarachnoid haemorrhage.
Constrictive structural elements in human cerebral arteries following aneurysmal subarachnoid haemorrhage.
复制标题
DOI：
10.1080/01616412.1987.11739793
复制
发表时间：
1987-09
影响因子：
1.9
通讯作者：
Robert R. Smith;B. Clower;J. Cruse;Yutaka Honma;Joseph L. Haining
中科院分区：
文献类型：
--
作者：
Robert R. Smith;B. Clower;J. Cruse;Yutaka Honma;Joseph L. Haining
组织免疫学、组织化学和组织学研究对4例近期发生动脉瘤性蛛网膜下腔出血的存活患者的脑动脉进行了研究。血管痉挛的严重程度似乎与病理结果的大小有关。在血管痉挛明显的动脉中，内层有大量的大肌成纤维细胞和V型胶原，但在受累程度较轻的动脉中不太明显。非脑源性死亡患者的颅内动脉没有表现出这些变化。在破裂的血管中，除中层外，肌动蛋白-肌球蛋白细丝在动脉壁各层也有阳性荧光。推测内、外膜肌动蛋白-肌球蛋白、肌成纤维细胞和V型胶原可能通过使受损血管在愈合过程中处于收缩状态而导致脑血管痉挛。
Histoimmunological, histochemical, and histological studies were conducted on cerebral arteries from four living patients with a recent aneurysmal subarachnoid haemorrhage. There appeared to be a correlation between the severity of vasospasm and the magnitude of pathological findings. Large myofibroblast cells and type V collagen within the medial layer were abundant in arteries showing marked vasospasm, but were less conspicuous in those showing milder involvement. Intracranial arteries from patients who died from non-cerebral causes did not demonstrate these changes. In ruptured vessels, there was also a positive fluorescence for actin-myosin filaments in layers of the arterial wall other than the media. It is postulated that the intimal and adventitial actin-myosin, myofibroblasts and type V collagen may contribute to cerebral vasospasm by holding the damaged vessel in a contracted phase during the healing period.