IGSF9 Family Proteins
IGSF9 Family Proteins
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DOI：
10.1007/s11064-013-0999-y
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发表时间：
2013-06-01
影响因子：
4.4
通讯作者：
Walmod, Peter Schledermann
中科院分区：
文献类型：
--
作者：
Hansen, Maria;Walmod, Peter Schledermann
果蝇蛋白 Turtle 和脊椎动物蛋白免疫球蛋白超家族 (IgSF) 成员 9 (IGSF9/Dasm1) 和 IGSF9B 是进化上古老的蛋白质家族的成员。对该蛋白质家族的生物信息学分析表明，无脊椎动物仅包含一个 IGSF9 家族基因，而脊椎动物则包含两到四个基因。在刺胞动物中，该基因似乎编码一种分泌蛋白，但该蛋白的跨膜亚型也已进化，并且在许多物种中，选择性剪接促进了跨膜亚型和分泌亚型的表达。在大多数物种中，最长的蛋白质亚型与细胞粘附分子蛋白质的神经细胞粘附分子家族具有相同的一般组织，并且与该蛋白质家族一样，IGSF9家族成员在神经系统中表达。文献综述表明，果蝇龟促进同种细胞粘附。此外，IGSF9家族蛋白与神经突的生长和分支、轴突引导、突触成熟、自我回避和平铺有关。然而，尽管关于 IGSF9 家族蛋白的研究很少，但关于海龟和哺乳动物 IGSF9 蛋白功能的报道是相互矛盾的。
The Drosophila protein Turtle and the vertebrate proteins immunoglobulin superfamily (IgSF), member 9 (IGSF9/Dasm1) and IGSF9B are members of an evolutionarily ancient protein family. A bioinformatics analysis of the protein family revealed that invertebrates contain only a single IGSF9 family gene, whereas vertebrates contain two to four genes. In cnidarians, the gene appears to encode a secreted protein, but transmembrane isoforms of the protein have also evolved, and in many species, alternative splicing facilitates the expression of both transmembrane and secreted isoforms. In most species, the longest isoforms of the proteins have the same general organization as the neural cell adhesion molecule family of cell adhesion molecule proteins, and like this family of proteins, IGSF9 family members are expressed in the nervous system. A review of the literature revealed that Drosophila Turtle facilitates homophilic cell adhesion. Moreover, IGSF9 family proteins have been implicated in the outgrowth and branching of neurites, axon guidance, synapse maturation, self-avoidance, and tiling. However, despite the few published studies on IGSF9 family proteins, reports on the functions of both Turtle and mammalian IGSF9 proteins are contradictory.