The descent of memory T cells
The descent of memory T cells
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DOI：
10.1111/j.1749-6632.2010.05830.x
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Schumacher, Ton N. M.
中科院分区：
文献类型：
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作者：
Gerlach, Carmen;van Heijst, Jeroen W. J.;Schumacher, Ton N. M.
我们的T细胞库是由抗原相遇形成的。病原体感染导致从包含数百万种不同的、未知特异性的T细胞的原始T细胞池中选择那些可以检测病原体来源的抗原的T细胞。在清除感染后，记忆T细胞群体仍然存在，并保护个人免受严重的再次感染。该领域的一个中心问题是，如何控制长寿命记忆T细胞的产生，而不是短寿命(“终末分化”)T细胞的产生。在这篇综述中，我们讨论了已提出的解释感染后记忆T细胞产生的模型以及支持这些假说的实验证据。基于现有的数据，我们提出了一个新的模型，该模型规定，在免疫反应期间，T细胞不会获得决定其后续长期生存的不同命运，而是呈现不同的状态，仅反映未来生存的可能性，这些状态仍然可以受到外部信号的调节。
Our T cell repertoire is shaped by antigen encounter. From a naive T cell pool that contains millions of different T cells with unknown specificities, pathogen infection leads to selection of those T cells that can detect pathogen-derived antigens. Following clearance of infection, a population of memory T cells remains and protects the individual from severe reinfection. A central question in the field has been how the generation of long-lived memory T cells, versus short-lived ("terminally differentiated") T cells, is controlled. In this review we discuss the models that have been put forward to explain the generation of memory T cells after infection and the experimental evidence supporting these hypotheses. Based on the available data we propose a new model that stipulates that during immune responses T cells do not acquire different fates that determine their subsequent long-term survival but rather T cells assume different states that simply reflect the likelihood of future survival, states that can still be modulated by external signals.