Distribution of tract deficits in schizophrenia.
Distribution of tract deficits in schizophrenia.
复制标题
精神分裂症中道缺陷的分布。
DOI：
10.1186/1471-244x-14-99
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发表时间：
2014-04-02
期刊：
影响因子：
4.4
通讯作者：
Cannon DM
中科院分区：
文献类型：
--
作者：
Ellison-Wright I;Nathan PJ;Bullmore ET;Zaman R;Dudas RB;Agius M;Fernandez-Egea E;Müller U;Dodds CM;Forde NJ;Scanlon C;Leemans A;McDonald C;Cannon DM
精神分裂症患者的大脑中发现了灰质和白质的变化，但这些变化背后的解剖组织过程仍不清楚。我们的目标是识别一组精神分裂症患者的灰质和白质体积变化，并使用一种新的方法来量化白质束变化的分布，该方法对扩散成像数据应用了三种互补分析。对21例精神分裂症患者和21例正常对照组进行了脑磁共振成像检查。使用基于体素的形态计量学(VBM)研究灰质和白质体积的差异。脑白质弥散变化使用基于脑束的空间统计学(TBSS)进行定位，并在标准图谱中进行量化。使用纤维束造影术检查有显著区域差异的区域。灰质或白质容量测定两组间差异无统计学意义。用TBSS测试，精神分裂症组的假发现率(FA值)显著低于对照组(P<0.05)，其中膝部、体部、压部和内囊的左前肢(ALIC)显著低于对照组。使用纤维束造影术，精神分裂症患者膝骨体的FA显著降低(p = 0.003)。在精神分裂症患者中，白质扩散缺陷在额叶内侧区域表现突出。这些变化与之前检测到这些区域白质变化的研究结果一致。精神分裂症的病理可能优先影响横跨这些区域的前额-丘脑白质回路。
Gray and white matter brain changes have been found in schizophrenia but the anatomical organizing process underlying these changes remains unknown. We aimed to identify gray and white matter volumetric changes in a group of patients with schizophrenia and to quantify the distribution of white matter tract changes using a novel approach which applied three complementary analyses to diffusion imaging data. 21 patients with schizophrenia and 21 matched control subjects underwent brain magnetic resonance imaging. Gray and white matter volume differences were investigated using Voxel-based Morphometry (VBM). White matter diffusion changes were located using Tract Based Spatial Statistics (TBSS) and quantified within a standard atlas. Tracts where significant regional differences were located were examined using fiber tractography. No significant differences in gray or white matter volumetry were found between the two groups. Using TBSS the schizophrenia group showed significantly lower fractional anisotropy (FA) compared to the controls in regions (false discovery rate <0.05) including the genu, body and splenium of the corpus callosum and the left anterior limb of the internal capsule (ALIC). Using fiber tractography, FA was significantly lower in schizophrenia in the corpus callosum genu (p = 0.003). In schizophrenia, white matter diffusion deficits are prominent in medial frontal regions. These changes are consistent with the results of previous studies which have detected white matter changes in these areas. The pathology of schizophrenia may preferentially affect the prefrontal-thalamic white matter circuits traversing these regions.