Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs
Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs
复制标题
活性氧在 AgNP 的辐射增强和自噬诱导中充当执行者的角色。
DOI：
10.1016/j.biomaterials.2016.05.031
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发表时间：
2016-09-01
期刊：
影响因子：
14
通讯作者：
Gu, Ning
中科院分区：
文献类型：
--
作者：
Wu, Hao;Lin, Jun;Gu, Ning
Malignant glioma is one of the most common intracranial tumor with a dismal prognosis. The radio sensitizing effect of silver nanoparticles (AgNPs) on glioma both in vitro and in vivo were demonstrated in the previous studies of our group. However, the underlying mechanism is still unclear. In this present study, the use of antioxidants is employed for the regulating of reactive oxygen species (ROS) in U251 cells treated with various agents, and the results shows that ROS played an essential role in the autophagy inducing and radiosensitization effect of AgNPs. Moreover, the inhibition of protective autophagy with 3-MA is another way to increase ROS, resulting in the increasing of cell death and apoptosis. Taken together, understanding the relationship between the elevated ROS and autophagy and the effect of ROS should be useful to the clinical applications of AgNPs. These findings could potentially be exploited for new therapeutic strategies in glioma radiotherapy. (C) 2016 Elsevier Ltd. All rights reserved.
