The shape of things to come: importance of design in nanotechnology for drug delivery.
The shape of things to come: importance of design in nanotechnology for drug delivery.
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DOI：
10.4155/tde.11.156
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发表时间：
2012-02
影响因子：
4.2
通讯作者：
Muzykantov VR
中科院分区：
文献类型：
--
作者：
Liu Y;Tan J;Thomas A;Ou-Yang D;Muzykantov VR
纳米粒子的大小、形状和表面化学结构的设计对其性能有重要影响。虽然颗粒大小和表面化学对药物释放的影响已经被广泛研究，但关于颗粒形状对纳米药物的影响却知之甚少。在这篇透视文章中，我们讨论了各种形状的纳米颗粒的设计和制备及其独特的输送性能的最新进展。这些药物载体的形状在治疗过程中起着重要的作用，如颗粒的黏附、分布和细胞内化。我们设想，能够主动改变其形状和其他性质的刺激响应型纳米粒子，可能会为下一代纳米医学铺平道路。
The design of nanoparticle (NP) size, shape and surface chemistry has a significant impact on their performance. While the influences of the particle size and surface chemistry on drug delivery have been studied extensively, little is known about the effect of particle shapes on nanomedicine. In this perspective article, we discuss recent progress on the design and fabrication of NPs of various shapes and their unique delivery properties. The shapes of these drug carriers play an important role in therapeutic delivery processes, such as particle adhesion, distribution and cell internalization. We envision that stimuli-responsive NPs, which actively change their shapes and other properties, might pave way to the next generation of nanomedicine.