Retinal microvascular structure and function in patients with risk factors of atherosclerosis and coronary artery disease
Retinal microvascular structure and function in patients with risk factors of atherosclerosis and coronary artery disease
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DOI：
10.1016/j.atherosclerosis.2013.12.044
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发表时间：
2014-04-01
期刊：
影响因子：
5.3
通讯作者：
Wong, Tien Y.
中科院分区：
文献类型：
--
作者：
Al-Fiadh, Ali H.;Farouque, Omar;Wong, Tien Y.
目的：视网膜微血管体征是心血管疾病风险的标志。关于视网膜微血管体征和视网膜微血管内皮功能之间关系的数据有限。我们试图确定视网膜血管的迹象与视网膜微血管内皮功能的患者或在高风险的冠状动脉diseases.Methods：参与者动脉粥样硬化的危险因素和冠状动脉疾病（n = 258，平均年龄57 +/- 11岁）的关系被招募到有静态和动态视网膜血管评估。使用数字血管分析仪测量响应闪烁光的视网膜小动脉扩张（FI-RAD），并表示为相对于基线直径的百分比增加。结果：闪光灯诱发的视网膜小动脉扩张的组内相关系数为0.82。两眼之间的视网膜血管测量值有一定的相关性。视网膜小动脉直径每减少10 mm，FI-RAD的绝对增加为0.28%（95%CI 0.11，0.45; p = 0.002），与年龄、性别和动脉粥样硬化风险因素无关。AVN和FAN与FI-RAD减弱有关（β = -0.67%; 95% CI-1.20，-0.15; p = 0.012）和（β = -0.83%; 95% CI-1.44，-0.23; p = 0.007）。视网膜微血管内皮功能的评估是可重复的，并与视网膜微血管结构和体征相关，独立于动脉粥样硬化的危险因素。视网膜血管结构和功能的评估可以提供洞察动脉粥样硬化性疾病。皇冠版权所有（C）2014由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: Retinal microvascular signs are markers of cardiovascular disease risk. There are limited data, on relationships between retinal microvascular signs and retinal microvascular endothelial function. We sought to determine the relationship of retinal vascular signs with retinal microvascular endothelial function in patients with or at high risk of coronary artery disease.Methods: Participants with atherosclerosis risk factors and coronary disease (n = 258; mean age 57 +/- 11 years) were recruited to have static and dynamic retinal vascular assessment. Retinal arteriolar dilatation in response to flicker light (FI-RAD) was measured using the Digital Vessel Analyser and expressed as percentage increase over baseline diameter. Static retinal photographs were acquired utilising a digital fundus camera for measurement of central retinal artery and vein equivalent (CRAE and CRVE), arteriovenous nicking (AVN) and focal arteriolar narrowing (FAN).Results: Intra-class correlation coefficient was 0.82 for flicker-light induced retinal arteriolar dilatation. There were modest associations in retinal vascular measurements between eyes. For each 10 mm decrease in retinal arteriolar diameter, the absolute increase in FI-RAD was 0.28% (95% CI 0.11, 0.45; p = 0.002) independent of age, gender and atherosclerosis risk factors. AVN and FAN were associated with attenuated FI-RAD (beta = -0.67%; 95% CI -1.20, -0.15; p = 0.012) and (beta = -0.83%; 95% CI -1.44, -0.23; p = 0.007) respectively after adjustment for age and gender.Conclusion: Assessment of retinal microvascular endothelial function is reproducible and correlated with retinal microvascular structure and signs, independent of atherosclerosis risk factors. Assessment of retinal vascular structure and function may provide insights into atherosclerotic disease. Crown Copyright (C) 2014 Published by Elsevier Ireland Ltd. All rights reserved.