Construction of [2,5]-Furanophanes by Carbene-Mediated Alkynyl Migration Cyclization
Construction of [2,5]-Furanophanes by Carbene-Mediated Alkynyl Migration Cyclization
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DOI：
10.1021/acs.orglett.2c03185
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发表时间：
2022-10-28
期刊：
影响因子：
5.2
通讯作者：
Zhu，Shifa
中科院分区：
文献类型：
--
作者：
Shi，Qiu;Chen，Yang;Zhu，Shifa
杂芳烷广泛存在于天然产物和药物分子中。在此基础上，发展了一种有效的方法来构建具有不同环类型和环大小的[2，5]-呋喃并吩。该方法通过分子内卡宾介导的炔基迁移和串联环化策略，用不含呋喃的前体进行。此外，产物经氧化偶联可得到一系列四呋喃结构。
Heterophanes are widely found in natural products and drug molecules. Herein, an efficient method for the construction of [2,5]-furanophanes with different ring types and ring sizes was developed. This method is carried out with furan-free precursor through intramolecular carbene-mediated alkynyl migration and tandem cyclization strategy. In addition, a series of tetrafuran structures can be obtained by oxidative coupling of the products.