Recent epidemiology of peste des petits ruminants virus (PPRV)
Recent epidemiology of peste des petits ruminants virus (PPRV)
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DOI：
10.1016/s0378-1135(02)00102-5
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发表时间：
2002-08-25
影响因子：
3.3
通讯作者：
Bandyopadhyay, SK
中科院分区：
文献类型：
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作者：
Dhar, P;Sreenivasa, BP;Bandyopadhyay, SK
小反刍兽疫（Peste des Petits Ruminants，PPR）是一种重要的山羊和绵羊病毒性疾病，最早于20世纪40年代在西非发现。该病毒在撒哈拉以南非洲部分地区传播了几十年，自1993年以来在中东和南亚传播，尽管印度首次描述该病毒可追溯到1987年。为了研究不同地理来源的分离株之间的遗传关系，采用RT/PCR扩增了病毒融合蛋白（F）基因的一个选定区域，并对所得DNA产物进行了测序，用于系统发育分析。将1993年至2000年期间在亚洲和中东国家报告的27起疫情以及最近在非洲大陆爆发的两起疫情的病毒与原型非洲毒株进行了比较。在PPR病毒的四个已知谱系中，谱系1和谱系2病毒仅在西非发现。1999年在布基纳法索爆发的病毒属于谱系I组。在东非发现了谱系3的病毒，1996年在埃塞俄比亚爆发的疫情就是这种类型，在阿拉伯半岛和印度南部也发现了这种病毒。然而，自1992年在泰米尔纳德邦报告以来，没有从印度进一步分离到谱系3病毒。2001年在也门发现了一种这种病毒。在过去的8年中，第四谱系的病毒已经传播到整个中东和亚洲次大陆，向东到达尼泊尔和孟加拉国。1999年在科威特也报告了该病毒谱系。新的谱系4病毒的地理来源尚不清楚，尽管它与非洲谱系1最密切相关。它早先在印度北方的存在被牛瘟病毒（一种与牛有关的病毒）的传播所掩盖的可能性被认为是不太可能的。(C)出版社：Elsevier Science B. V.
Peste des petits ruminants (PPR) is an economically important viral disease of goats and sheep first described in west Africa in the 1940s. The virus has been circulating in parts of sub-Saharan Africa for several decades and in the Middle East and southern Asia since 1993, although the first description of the virus in India dates to 1987. To study the genetic relationship between isolates of distinct geographical origin, a selected region of the fusion (F) protein gene of the viruses was amplified using RT/PCR and the resulting DNA product sequenced for phylogenetic analysis. Viruses from 27 outbreaks in Asian and Middle Eastern countries, reported between 1993 and 2000, and two recent outbreaks from the African continent were compared with the prototype African strain. Of the four known lineages of PPR virus, lineage 1 and 2 viruses have been found exclusively in west Africa. Virus from an outbreak in Burkina Faso in 1999 fell into the lineage I group. Viruses of lineage 3 have been found in east Africa, where an outbreak in Ethiopia in 1996 was of this type, and also in Arabia and in southern India. However, there have been no further isolations of lineage 3 virus from India since the one reported in 1992 from Tamil Nadu. A virus of this lineage was found circulating in Yemen in 2001. In the past 8 years virus exclusively of the fourth lineage has spread across the Middle East and the Asian sub-continent, reaching east as far as Nepal and Bangladesh. This virus lineage was also reported from Kuwait in 1999. The geographical source of the new lineage 4 virus is unknown although it is most closely related to African lineage 1. The possibility that its earlier presence in northern India was masked by the circulation of Rinderpest virus, a related virus of cattle, is considered unlikely. (C) 2002 Published by Elsevier Science B.V.