Decrease in serum levels of vitamin A and zeaxanthin in patients with colorectal polyp.
Decrease in serum levels of vitamin A and zeaxanthin in patients with colorectal polyp.
复制标题
结直肠息肉患者血清维生素 A 和玉米黄质水平降低。
DOI：
10.1097/00042737-199903000-00015
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
G. Mózsik
中科院分区：
文献类型：
--
作者：
G. Rumi;I. Szabo;Á. Vincze;Z. Matus;G. Tóth;G. Rumi;G. Mózsik
目标
一些回顾性和前瞻性流行病学调查表明，富含类胡萝卜素的饮食可以预防消化道癌前病变和肿瘤病变的发展。本检查的目的是分析不同组织学分类的结直肠息肉与血清类胡萝卜素水平的相关性。
设计与方法
结肠镜诊断后，对所有患者采集10ml血样。采用高压液相色谱法 (HPLC) 测定腺瘤性结直肠息肉患者（n = 59、男性 35 例、女性 24 例）维生素 A、叶黄素、玉米黄质、α-和 β-隐黄质、α-和 β-胡萝卜素的血清水平，并与健康受试者（n = 20、10 名男性、10 名女性）进行比较。根据组织学结果，将患者分为四组。
结果
所有息肉患者的血清维生素A和玉米黄质水平（维生素A：0.913+/-0.112微摩尔/升，玉米黄质：0.071+/-0.012微摩尔/升）显着低于对照组健康组（维生素A：2.036+/-0.354微摩尔/升，玉米黄质：0.138+/-0.138+/- 0.048 微摩尔/升）。息肉中局灶性腺癌患者的水平最低。其他类胡萝卜素的血清水平没有显着差异。这些患者的血清胆固醇、血红蛋白、总蛋白和白蛋白水平均正常。
结论
血清类胡萝卜素水平与不同组织学分级的结直肠息肉之间存在密切的负相关关系。息肉腺癌患者的类胡萝卜素平均水平较低，表明类胡萝卜素缺乏可能是结直肠癌发生的一个重要因素。
OBJECTIVE
Several retrospective and prospective epidemiological investigations have demonstrated that a diet rich in carotenoids could prevent the development of pre-cancerous and neoplastic lesions of the digestive tract. The aim of this examination was to analyse the correlation between colorectal polyps with different histological classifications and serum carotenoid levels.
DESIGN AND METHODS
A 10 ml blood sample was taken from all of the patients after the colonoscopic diagnosis. The serum levels of vitamin A, lutein, zeaxanthin, alpha- and beta-cryptoxanthin, alpha- and beta-carotene were measured in patients with adenomatous colorectal polyp (n = 59, 35 males, 24 females) by high-pressure liquid chromatography (HPLC) and compared with those in healthy subjects (n = 20, 10 males, 10 females). The patients were separated into four groups depending on their histological findings.
RESULTS
The serum levels of vitamin A and zeaxanthin were significantly lower in all patients with polyps (vitamin A: 0.913 +/- 0.112 micromol/l, zeaxanthin: 0.071 +/- 0.012 micromol/l) than in the control healthy group (vitamin A: 2.036 +/- 0.354 micromol/l, zeaxanthin: 0.138 +/- 0.048 micromol/l). The lowest levels were found in patients with focal adenocarcinoma in the polyp. There were no significant differences in the serum levels of other carotenoids. The serum levels of cholesterol, haemoglobin, total protein and albumin were normal in these patients.
CONCLUSIONS
There are close and inverse correlations between the serum level of carotenoids and colorectal polyps with different histological grades. The low mean carotenoid levels in patients with adenocarcinoma in the polyp indicate that deficiency of carotenoids may be an important factor in the development of colorectal cancer.