Pharyngeal arch patterning in the absence of neural crest
Pharyngeal arch patterning in the absence of neural crest
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DOI：
10.1016/s0960-9822(00)80118-9
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发表时间：
1999-12-16
期刊：
影响因子：
9.2
通讯作者：
Graham, A
中科院分区：
文献类型：
--
作者：
Veitch, E;Begbie, J;Graham, A
咽弓是发育中的脊椎动物头的突出特征。它们构成了一系列的凸起，肌肉和骨骼元素形成。重要的是，这些组织源自不同的胚胎细胞类型[1]，许多研究强调了颅神经rest的作用，颅骨成分从中衍生出来，在咽弓[2-4]中构图。但是，从来没有清楚的是，所有弓形图案是否完全取决于这种单元格。在这里，我们表明，咽弓形成与波峰迁移的过程没有耦合，此外，咽弓形成形成，是区域化的，即使在没有神经crest的情况下也具有认同感。因此，现在可以将脊椎动物的头部形态发生视为一个比以前认为的更复杂的过程，并且必须归因于神经依赖性和非依赖性的构图机制的整合。我们的结果还反映了以下事实：咽部分割的进化起源早于神经rest的进化起源，这是一个仅是脊椎动物的特征。 （c）1999 Elsevier Science Ltd.保留所有权利。
Pharyngeal arches are a prominent and critical feature of the developing vertebrate head. They constitute a series of bulges within which musculature and skeletal elements form; importantly, these tissues derive from different embryonic cell types [1], Numerous studies have emphasised the role of the cranial neural crest, from which the skeletal components derive, in patterning the pharyngeal arches [2-4]. It has never been clear, however, whether all arch patterning is completely dependent on this cell type. Here, we show that pharyngeal arch formation is not coupled to the process of crest migration and, furthermore, that pharyngeal arches form, are regionalised and have a sense of identity even in the absence of the neural crest. Thus, vertebrate head morphogenesis can now be seen to be a more complex process than was previously believed and must result from an integration of both neural-crest-dependent and -independent patterning mechanisms. Our results also reflect the fact that the evolutionary origin of pharyngeal segmentation predates that of the neural crest, which is an exclusively vertebrate characteristic. (C) 1999 Elsevier Science Ltd. All rights reserved.