Strengthening associations between psychotic like experiences and suicidal ideation and behavior across middle childhood and early adolescence.
Strengthening associations between psychotic like experiences and suicidal ideation and behavior across middle childhood and early adolescence.
复制标题
加强童年中期和青春期早期精神病样经历与自杀意念和行为之间的联系。
DOI：
10.1017/s0033291722003166
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发表时间：
2023
影响因子：
6.9
通讯作者：
Grattan,Rebecca
中科院分区：
文献类型：
--
作者：
Karcher,NicoleR;O'Hare,Kirstie;Jay,SamanthaY;Grattan,Rebecca
背景了解青少年自杀意念（SI）和自杀行为（SB）的相关危险因素对预防和干预工作具有重要意义。虽然在整个生命的不同阶段，类精神病经历（ple）似乎与SI和SB密切相关，但这种关系在童年中期和青春期早期的纵向性质尚未得到充分研究。方法采用独特的纵向青少年大脑认知发展研究数据。混合效应线性模型使用9-13岁的三个时间点数据来检验ple、SI和SB之间随时间的关系。结果：首先，分析表明，随着年龄的增长，那些痛苦的ple增加的人对SI和SB的认可增加。分析发现，ple与SI和SB之间存在双向关系，基线时的ple与SI和SB随时间的恶化有关，包括从SI到SB的转变（β = 0.032, FDRp = 0.002）。探索性分析显示，有一致的证据表明，随着时间的推移，SI和SB的高妄想观念（βs = 0.04, FDRp < 0.001）和SB的知觉扭曲（βs = 0.046, FDRp < 0.001）都有加强的关联。当考虑到一般精神病理时，与一般精神病理（β = 0.022, FDRp = 0.01）相比，随着时间的推移，SB与PLEs的相关性显著增强（β = 0.053, FDRp < 0.001）。结论：随着时间的推移，SI和SB与ple的相关性增强，基线ple可能预示着随着时间的推移自杀倾向的恶化。随着时间的推移，这些发现对青少年报告的ple和自杀之间的联系的本质进行了重要的澄清。
BackgroundUnderstanding risk factors related to suicidal ideation (SI) and suicidal behaviors (SB) in youth is important for informing prevention and intervention efforts. While it appears that psychotic-like experiences (PLEs) are strongly associated with both SI and SB at different points across the lifespan, the longitudinal nature of this relationship in middle childhood and early adolescence is understudied.MethodsThe study used the unique longitudinal Adolescent Brain Cognitive Development Study data. Mixed effects linear models examined associations between PLEs and SI and SB over time using three time points of data from ages 9–13.ResultsFirst, analyses indicated that endorsement of SI and SB increased as youth grew older for those with increased distressing PLEs. Analyses found evidence of bidirectional relationships between PLEs with SI and SB, with evidence that PLEs at baseline were associated with worsening SI and SB over time, including a transition from SI to SB (β = 0.032, FDRp = 0.002). Exploratory analyses showed consistent evidence for strengthened associations over time for higher delusional ideation with both SI and SB (βs > 0.04, FDRps < 0.001), and for perceptual distortions with SB (βs = 0.046, FDRp < 0.001). When accounting for general psychopathology, for SB, the strengthened associations over time was significantly stronger for PLEs (β = 0.053, FDRp < 0.001) compared to general psychopathology (β = 0.022, FDRp = 0.01).ConclusionsThe present study indicates both SI and SB show strengthened associations with PLEs over time, and that baseline PLEs may predict worsening of suicidality over time. The findings are important clarifications about the nature of the associations between youth-reported PLEs and suicidality over time.