In vitro activity of linezolid and other antibiotics against Gram-positive bacteria from the major teaching hospitals in Kuwait
In vitro activity of linezolid and other antibiotics against Gram-positive bacteria from the major teaching hospitals in Kuwait
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DOI：
10.1179/joc.2005.17.6.607
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发表时间：
2005-12-01
影响因子：
1.8
通讯作者：
Rotimi, VO
中科院分区：
文献类型：
--
作者：
Al Sweih, N;Mokaddas, E;Rotimi, VO
耐多药革兰氏阳性菌是临床日益紧迫的问题。因此，采用Etest、圆盘扩散和Vitek方法，对最近引进的具有革兰氏阳性活性的恶唑烷酮利奈唑胺与其他10种抗生素对8103种临床显著的革兰氏阳性球菌进行了比较试验。利奈唑胺对所有菌株均有良好的抑菌活性。万古霉素和替柯planin对几乎所有的菌株都表现出同样优异的活性。耐甲氧西林金黄色葡萄球菌（MRSA）对糖肽和利奈唑胺均敏感，但对红霉素（96%）、福西地酸（91.5%）、庆大霉素（84%）和克林霉素（73%）耐药。分离的肺炎链球菌对青霉素（MIC > 0.5 μ g/ml）和红霉素（MIC > 1 μ g/ml）分别有41%和39%的耐药。无乳链球菌对克林霉素和红霉素的耐药率分别为9%和10%。结果表明，所有革兰氏阳性菌株对利奈唑胺敏感。鉴于其口服生物利用度，它显然具有很大的前景。我们的数据应该是对中东文献的有益补充。
Multidrug-resistant Gram-positive bacteria are an increasingly pressing problem in the clinic. Consequently, linezolid, a recently introduced oxazolidinone with Gram-positive activity, was tested in comparison with 10 other antibiotics against 8103 clinically significant Gram-positive cocci by Etest, disk diffusion and Vitek methods. Linezolid demonstrated excellent activities against all isolates. Vancomycin and teicoplanin demonstrated equally excellent activity against almost all isolates. The methicillin-resistant Staphylococcus aureus (MRSA) strains were all susceptible to the glycopeptides and linezolid, but resistant to erythromycin (96%), fusidic acid (91.5%), gentamicin (84%) and clindamycin (73%). Forty one and 39% of the Streptococcus pneumoniae isolates were resistant to penicillin (MIC > 0.5 mu g/ml) and erythromycin (MIC > 1 mu g/ml), respectively. S. agalactiae susceptibility was 9% and 10% resistant to clindamycin and erythromycin, respectively. In conclusion, all the Gram-positive isolates tested were susceptible to linezolid. With its oral bioavailability profiles, it obviously holds great promise. Our data should be a useful addition to the literature from the Middle East.