Organization and evolution of the alcohol dehydrogenase gene in Drosophila.
Organization and evolution of the alcohol dehydrogenase gene in Drosophila.
复制标题
果蝇乙醇脱氢酶基因的组织和进化。
DOI：
10.1093/oxfordjournals.molbev.a040487
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发表时间：
1988
影响因子：
10.7
通讯作者：
Moore,GP
中科院分区：
文献类型：
--
作者：
Cohn,VH;Moore,GP
从拟果蝇（Drosophila simulans）和果蝇（D. mauritiana，并确定了每种的4.6-kb区域的DNA序列，该区域含有结构基因和侧翼序列。并与D.黑腹果蝇的特征变化发生在果蝇基因组在进化过程中，并确定保守序列的功能重要性。Drosophila simulans和D. mauritiana Adh的组织方式与D.黑腹果蝇Adh，包括单个Adh基因的两个启动子的存在。这项研究确定了保守的侧翼元件，结合其他研究，建议可能参与控制Adh表达的区域。物种间和物种内的比较揭示了积累的序列变化的差异。Adh基因内部和周围的序列差异被用来评估种间和种内的进化关系。最后，似乎有一个不相关的结构基因直接位于Adh转录区的3'端。
The alcohol dehydrogenase (Adh) gene was isolated from Drosophila simulans and D. mauritiana, and the DNA sequence of a 4.6-kb region, containing the structural gene and flanking sequence, was determined for each. These sequences were compared with the Adh region of D. melanogaster to characterize changes that occur in the Drosophila genome during evolution and to identify conserved sequences of functional importance. Drosophila simulans and D. mauritiana Adh are organized in a manner similar to that of D. melanogaster Adh, including the presence of two promoters for the single Adh gene. This study identified conserved flanking elements that, in conjunction with other studies, suggest regions that may be involved in the control of Adh expression. Inter- and intraspecies comparisons revealed differences in the kinds of sequence changes that have accumulated. Sequence divergence in and around the Adh gene was used to assess inter- and intraspecies evolutionary relationships. Finally, there appears to be an unrelated structural gene located directly 3' of the Adh transcribed region.