THE EYES ABSENT GENE - GENETIC-CONTROL OF CELL-SURVIVAL AND DIFFERENTIATION IN THE DEVELOPING DROSOPHILA EYE
THE EYES ABSENT GENE - GENETIC-CONTROL OF CELL-SURVIVAL AND DIFFERENTIATION IN THE DEVELOPING DROSOPHILA EYE
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DOI：
10.1016/0092-8674(93)90115-7
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发表时间：
1993-02-12
期刊：
影响因子：
64.5
通讯作者：
BENZER, S
中科院分区：
文献类型：
--
作者：
BONINI, NM;LEISERSON, WM;BENZER, S
Eya基因在果蝇发育的早期阶段是必需的。复眼在Eya突变体中，视盘中的祖细胞在形态发生沟之前经历程序性细胞死亡，而不是进入视网膜分化的途径。低水平的细胞死亡通常发生在这个阶段，表明Eya活性影响分化和死亡之间的细胞分布。分子分析鉴定了在分化前在祖细胞中表达的核蛋白。用cDNA转化可以防止祖细胞死亡，并允许产生眼睛的事件继续进行。EYA活性是眼祖细胞在形态发生的关键阶段存活所必需的。
The eyes absent (eya) gene is required at an early stage in development of the D. melanogaster compound eye. In eya mutants, progenitor cells in the eye disc undergo programmed cell death anterior to the morphogenetic furrow, rather than proceeding into the pathway of retinal differentiation. A low level of cell death normally occurs at this stage, suggesting that eya activity influences the distribution of cells between differentiation and death. Molecular analysis identifies a nuclear protein expressed in progenitor cells prior to differentiation. Transformation with the cDNA prevents progenitor cell death and allows the events that generate the eye to proceed. eya activity is required for the survival of eye progenitor cells at a critical stage in morphogenesis.