Association between periodontitis and risk of Alzheimer′s disease, mild cognitive impairment and subjective cognitive decline: A case-control study
Association between periodontitis and risk of Alzheimer′s disease, mild cognitive impairment and subjective cognitive decline: A case-control study
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DOI：
10.1111/jcpe.13016
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发表时间：
2018-11-01
影响因子：
6.7
通讯作者：
Buhlin, Kare
中科院分区：
文献类型：
--
作者：
Holmer, Jacob;Eriksdotter, Maria;Buhlin, Kare
目的 检验牙周病会增加轻度认知障碍 (MCI)、主观认知能力下降 (SCD) 和阿尔茨海默病 (AD) 风险的假设。材料和方法 结果 这项病例对照研究在瑞典胡丁厄市进行了为期 3 年的研究。卡罗林斯卡大学医院卡罗林斯卡记忆诊所连续招募了 154 例病例，并分为三个诊断组：AD、MCI 和 SCD，统称为“病例”。通过瑞典人口登记册随机抽取了 76 名认知健康、年龄和性别匹配的对照组。所有病例和对照均接受临床和放射学口腔检查。统计分析基于针对潜在混杂因素进行调整的逻辑回归模型。口腔健康状况不佳和边缘牙槽骨丢失在病例中比对照组更普遍。病例组与广泛的边缘牙槽骨丢失（比值比[OR] = 5.81；95%置信区间[CI] = 1.14-29.68）、深牙周袋数量增加（OR = 8.43；CI 4.00-17.76）和龋齿（OR = 3.36；CI 1.20-9.43）相关。结论 结果表明边缘牙周炎与早期认知障碍和 AD 相关。然而，研究设计并不排除非因果解释。
Aims To test the hypothesis that periodontal disease contributes to increased risk of mild cognitive impairment (MCI), subjective cognitive decline (SCD) and Alzheimer ' s disease (AD). Materials and methods Results This case-control study was conducted over a 3-year period in the municipality of Huddinge, Sweden. In total, 154 cases were consecutively enrolled from the Karolinska Memory Clinic at the Karolinska University Hospital and allotted to three diagnostic groups: AD, MCI and SCD, collectively referred to as "cases." Seventy-six cognitively healthy age- and gender-matched controls were randomly sampled through the Swedish population register. All cases and controls underwent clinical and radiographic oral examinations. Statistical analysis was based on logistic regression models adjusted for potential confounders. Poor oral health and marginal alveolar bone loss were more prevalent among cases than among controls. The cases group was associated with generalized marginal alveolar bone loss (odds ratio [OR] = 5.81; 95% confidence interval [CI] = 1.14-29.68), increased number of deep periodontal pockets (OR = 8.43; CI 4.00-17.76) and dental caries (OR = 3.36; CI 1.20-9.43). Conclusion The results suggest that marginal periodontitis is associated with early cognitive impairment and AD. However, the study design does not preclude noncausal explanations.