Muscular thin films for building actuators and powering devices
Muscular thin films for building actuators and powering devices
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DOI：
10.1126/science.1146885
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发表时间：
2007-09-07
期刊：
影响因子：
56.9
通讯作者：
Parker, Kevin Kit
中科院分区：
文献类型：
--
作者：
Feinberg, Adam W.;Feigel, Alex;Parker, Kevin Kit
我们展示了由工程组织和合成聚合物薄膜组装的生物杂化材料。构建的方法是将新生大鼠心室心肌细胞培养在细胞外基质蛋白微图案的聚二甲基硅氧烷薄膜上，以促进空间有序的二维肌肉形成。这种结构被称为肌肉薄膜，当从热敏聚合物基板上释放时，采用功能性的三维构象，并被设计用于通过改变组织结构、薄膜形状和电起搏协议来执行仿生任务。这些厘米级的结构具有各种各样的功能，如抓握、抽吸、行走和游泳，具有精细的空间和时间控制，并产生高达每平方毫米4千牛顿的特定力。
We demonstrate the assembly of biohybrid materials from engineered tissues and synthetic polymer thin films. The constructs were built by culturing neonatal rat ventricular cardiomyocytes on polydimethylsiloxane thin films micropatterned with extracellular matrix proteins to promote spatially ordered, two-dimensional myogenesis. The constructs, termed muscular thin films, adopted functional, three-dimensional conformations when released from a thermally sensitive polymer substrate and were designed to perform biomimetic tasks by varying tissue architecture, thin-film shape, and electrical-pacing protocol. These centimeter-scale constructs perform functions as diverse as gripping, pumping, walking, and swimming with fine spatial and temporal control and generating specific forces as high as 4 millinewtons per square millimeter.