Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma.
Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma.
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DOI：
10.2147/opth.s22093
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Nakazawa T
中科院分区：
文献类型：
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作者：
Aizawa N;Yokoyama Y;Chiba N;Omodaka K;Yasuda M;Otomo T;Nakamura M;Fuse N;Nakazawa T
激光散斑血流图（LSFG）能够无创量化青光眼患者的视网膜循环。在这项研究中，我们测试了LSFG-NAVI，一种改进的LSFG技术的会话内重现性。本研究检查了33例受试者（男：女= 17：16）的65只眼，平均年龄为49.4 ± 11.2岁。在使用LSFG-NAVI测量平均模糊率（MBR）的同一天，对指示重现性的两个参数-变异系数（COV）和组内相关系数（ICC）进行了三次分析。分析的部位是视网膜动脉和静脉、视盘和脉络膜。根据青光眼半视野试验（GHT; SITA标准30-2程序）进行分类后，对有（GHT+; 38只眼，M：F = 20：18，平均年龄48.9 ± 12.8岁）和无（GHT-; 27只眼，M：F = 13：14，平均年龄50.1 ± 8.7岁）异常青光眼视野的患者进行COV和ICC检查。对于所有受试者，视盘（COV：3.4 ± 2.0; ICC：0.95）和脉络膜（COV：4.7 ± 3.4; ICC：0.98）的MBR的序列内重复性非常好。视网膜静脉（COV：8.4 ± 5.6，ICC：0.90）和视网膜动脉（COV：10.9 ± 9.9，ICC：0.9）的重复性中等。GHT+组（COV：3.8 ± 2.0; ICC：0.97）和GHT-组（COV：2.9 ± 2.1; ICC：0.95）视盘中的MBR具有良好的再现性。对正常人和青光眼患者的视盘进行了局部评估，结果表明，象限视盘区的COV在MBR的颞区最好（分别为3.4%，4.2%）。LSFG-NAVI在评价青光眼患者的视网膜循环，特别是在视盘和脉络膜中显示出良好的重复性。
Laser speckle flowgraphy (LSFG) enables noninvasive quantification of the retinal circulation in glaucoma patients. In this study, we tested the intrasession reproducibility of LSFG-NAVI, a modified LSFG technique. Sixty-five eyes from 33 subjects (male (M):female (F) = 17:16) with a mean age of 49.4 ± 11.2 years were examined in this study. Two parameters indicating reproducibility – the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) – were analyzed three times on the same day that mean blur rate (MBR) was measured using LSFG-NAVI. The sites analyzed were the retinal artery and vein, the optic disk, and the choroid. Following classification according to the Glaucoma Hemifield Test (GHT; SITA-Standard 30-2 program), the COV and ICC were examined in patients with (GHT+; 38 eyes, M:F = 20:18, average age 48.9 ± 12.8 years) and without (GHT−; 27 eyes, M:F = 13:14, average age 50.1 ± 8.7 years) abnormal glaucomatous visual fields. For all subjects, the intrasession reproducibility of MBR in the optic disk (COV: 3.4 ± 2.0; ICC: 0.95) and choroid (COV: 4.7 ± 3.4; ICC: 0.98) was excellent. The reproducibility for the retinal vein (COV: 8.4 ± 5.6, ICC: 0.90) and retinal artery (COV: 10.9 ± 9.9, ICC: 0.9) was moderate. MBRs in the optic disk had good reproducibility in both the GHT+ group (COV: 3.8 ± 2.0; ICC: 0.97) and the GHT− group (COV: 2.9 ± 2.1; ICC: 0.95). Local assessment of the optic disk in normal or glaucoma patients showed that the COVs of the quadrant optic disk areas were best in the temporal area of MBR (3.4%, 4.2%, respectively). LSFG-NAVI showed favorable reproducibility in evaluation of retinal circulation of glaucoma patients, particularly in the optic disk and choroid.