Type 1 Choroidal Neovascularization Lesion Size: Indocyanine Green Angiography Versus Optical Coherence Tomography Angiography
Type 1 Choroidal Neovascularization Lesion Size: Indocyanine Green Angiography Versus Optical Coherence Tomography Angiography
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DOI：
10.1167/iovs.15-18830
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发表时间：
2016-10-01
影响因子：
4.4
通讯作者：
Souied, Eric H.
中科院分区：
文献类型：
--
作者：
Costanzo, Eliana;Miere, Alexandra;Souied, Eric H.
目的。通过光学相干断层扫描血管造影（OCTA）评估新生血管AMD中1型脉络膜新生血管（CNV）的大小，并与吲哚菁绿血管造影（ICGA）进行比较。方法。诊断为 1 型 CNV 的患者接受了荧光素血管造影 (FA)、ICGA、频域 (SD)-OCT 和 OCTA 多模态成像。病灶大小通过 OCTA 测量脉络膜毛细血管水平的“选择区域”和“血管区域”功能，并结合在 AngioVue 软件中以及中期和晚期的 ICGA 上，由两个蒙面独立读数器测量。结果。分析中包括 17 名患者（平均年龄 80.6 +/- 8.36）的 19 只眼睛。平均视力为 0.2 logMAR。所有 OCTA 均显示脉络膜毛细血管分割中有高流量的新生血管网络。在 OCTA 上，读者 1 和 2 之间的组间相关性对于选定区域为 0.96（95% 置信区间 [CI] 0.94-0.99），对于血管区域为 0.97（95% CI 0.96-0.99）。在所有眼睛中均检测到 OCTA 与 ICGA 中病灶大小之间的差异，并且对于两位读者而言均具有统计学显着性 (P < 0.05)。 结论。光学相干断层扫描血管造影可提供 1 型 CNV 的定量和定性信息，并成为评估 CNV 面积和血管面积的新的可重复方法。 OCTA 和 ICGA 中期和晚期脉络膜毛细血管分割中的 1 型 CNV 病变大小显示 OCTA 大小明显小于 ICGA 大小。这支持了这样的观点：OCTA 可被考虑用于评估新生血管病变和评估治疗反应。
PURPOSE. To evaluate the size of type 1 choroidal neovascularization (CNV) in neovascular AMD by optical coherence tomography angiography (OCTA) and to compare with indocyanine green angiography (ICGA).METHODS. Patients diagnosed type 1 CNV underwent multimodal imaging by fluorescein angiography (FA), ICGA, spectral-domain (SD)-OCT, and OCTA. Lesion size was measured both on OCTA at the choriocapillaris level with "select area'' and "vessel area'' functions, incorporated in AngioVue software and on ICGA at intermediate and late phases, by two masked independent readers.RESULTS. Nineteen eyes of 17 patients (mean age 80.6 +/- 8.36) were included in the analysis. Mean visual acuity was 0.2 logMAR. All OCTA revealed a high flow neovascular network in the choriocapillaris segmentation. On OCTA, interclass correlation between readers 1 and 2 was 0.96 (95% confidence interval [CI] 0.94-0.99) for select area and 0.97 (95% CI 0.96-0.99) for vessel area. The difference between lesion size in OCTA versus ICGA was detected in all eyes and it was statistically significant for both readers (P < 0.05).CONCLUSIONS. Optical coherence tomography angiography provides both quantitative and qualitative information on type 1 CNV and appears as a new reproducible way to evaluate CNV area and vessels area. Type 1 CNV lesion size in the choriocapillaris segmentation of OCTA and ICGA intermediate and late phases revealed that the OCTA size is significantly smaller than the ICGA size. This supports the idea that OCTA could be considered for evaluation of the neovascular lesion and for evaluation of therapeutic responses.