The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease
The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease
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发表时间：
2016-12
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通讯作者：
L. O’Connor;J. Gilmour;C. Bonifer
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作者：
L. O’Connor;J. Gilmour;C. Bonifer
Sp1属于强Sp/KLF转录因子家族的26个成员。它是一种普遍表达的转录因子的范例，并参与调节与哺乳动物细胞中广泛的细胞过程相关的基因表达。Sp1可以与一系列蛋白质相互作用，包括其他转录因子、转录起始复合体成员和表观遗传调控因子，从而实现对其靶基因的严格调控。在这篇综述中，我们讨论了参与sp1介导的转录调节的机制，以及一个无处不在的转录因子如何参与建立组织特异性的基因表达模式以及其活性可能被调节的机制。我们还考虑Sp1在人类疾病（如癌症）中的作用。
Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm for a ubiquitously expressed transcription factor and is involved in regulating the expression of genes associated with a wide range of cellular processes in mammalian cells. Sp1 can interact with a range of proteins, including other transcription factors, members of the transcription initiation complex and epigenetic regulators, enabling tight regulation of its target genes. In this review, we discuss the mechanisms involved in Sp1-mediated transcriptional regulation, as well as how a ubiquitous transcription factor can be involved in establishing a tissue-specific pattern of gene expression and mechanisms by which its activity may be regulated. We also consider the role of Sp1 in human diseases, such as cancer.