Synthesis, resolution and racemisation studies of new tridentate ligands for asymmetric catalysis
Synthesis, resolution and racemisation studies of new tridentate ligands for asymmetric catalysis
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DOI：
10.1016/j.tetlet.2005.04.139
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发表时间：
2005-07-04
影响因子：
1.8
通讯作者：
Guiry, PJ
中科院分区：
文献类型：
--
作者：
Sweetman, BA;Müller-Bunz, H;Guiry, PJ
描述了一种用于高产率制备两个三齿异喹啉衍生配体的方法，包括连续的Suzuki交叉偶联反应。第一种配体可通过与N-苄基辛可尼丁氯化物的分子络合作用拆分，而第二种配体可通过其差向异构体樟脑磺酸盐的色谱分离拆分。通过外消旋研究评价了围绕中心联芳基轴旋转的障碍，并通过X射线晶体学分配了绝对构型。(c)2005爱思唯尔有限公司保留所有权利。
A method for the high-yielding preparation of two tridentate, isoquinoline-derived ligands, involving successive Suzuki cross-coupling reactions, is described. The first ligand Could be resolved via molecular complexation with N-benzylcinchonidinium chloride, while the second was resolved by chromatographic separation of its epimeric carnphorsulfonates. The barrier to rotation about the central biaryl axis was evaluated via racemisation Studies, and the absolute configuration assigned by X-ray crystallography. (c) 2005 Elsevier Ltd. All rights reserved.