Analyzing the Usage of Standards in Radiation Therapy Clinical Studies.
Analyzing the Usage of Standards in Radiation Therapy Clinical Studies.
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分析放射治疗临床研究中标准的使用。
DOI：
10.1109/bhi.2017.7897277
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Ge,Y
中科院分区：
文献类型：
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作者：
Zhen,Y;Jiang,Y;Yuan,L;Kirkpartrick,J;Wu,J;Ge,Y
放射治疗(RT)后不良反应的评分标准对于大规模和跨多项研究的毒性结果的综合、一致和准确分析至关重要。该项目旨在通过开发基于文本挖掘的分析方法来调查已发表的RT临床研究中最常用的三个标准的使用情况。我们开发并比较了两种文本挖掘方法，一种基于正则表达式，另一种基于朴素贝叶斯分类器，以分析已发表的全文文章在RT中采用的标准。完整的数据集包括MEDLINE在2010年1月至2015年8月期间发表的文章。放射肿瘤内科医生审阅了培训/验证子集中的所有文章，并手动生成使用趋势数据作为验证的黄金标准。基于正则表达式的方法报告的分类和总体使用趋势与领域专家的分类和总体使用趋势相当。随着时间的推移，CTCAE标准正在成为总体上最常用的标准，但采用的速度似乎非常缓慢。对结果的进一步检查表明，使用情况因疾病类型而异。这表明需要进一步努力来改进和协调RT研究界的不良反应评分标准。
Standards for scoring adverse effects after radiation therapy (RT) is crucial for integrated, consistent, and accurate analysis of toxicity results at large scale and across multiple studies. This project aims to investigate the usage of the three most commonly used standards in published RT clinical studies by developing a text-mining based analysis method. We develop and compare two text-mining methods, one based on regular expressions and one based on Naïve Bayes Classifier, to analyze published full articles in terms of their adoption of standards in RT. The full dataset includes published articles identified in MEDLINE between January 2010 and August 2015. A radiation oncology physician reviewed all the articles in the training/validation subset and produced the usage trending data manually as gold standard for validation. The regular-expression based method reported classifications and overall usage trends that are comparable to those of the domain expert. The CTCAE standard is becoming the overall most commonly used standards over time, but the pace of adoption seems very slow. Further examination of the results indicates that the usage vary by disease type. It suggests that further efforts are needed to improve and harmonize the standards for adverse effects scoring in RT research community.