A new strategy for simultaneous synthesis and efficient anchorage of polymer monoliths in native PDMS microchips
A new strategy for simultaneous synthesis and efficient anchorage of polymer monoliths in native PDMS microchips
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DOI：
10.1016/j.polymer.2015.04.039
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发表时间：
2015-06-01
期刊：
影响因子：
4.6
通讯作者：
Thuy Tran, N.
中科院分区：
文献类型：
--
作者：
Araya-Farias, Monica;Taverna, Myriam;Thuy Tran, N.
我们在此报告了一种一锅法，首次实现了聚合物整体在天然 PDMS 通道中的同时合成/锚定。通过光驱动过程在 PDMS 微芯片内合成由乙二醇甲基丙烯酸酯磷酸酯 (EGMP) 和 N,N'-亚甲基双丙烯酰胺 (BAA) 组成的整体材料。 EGMP单体从未用于此目的。为了实现该方法，研究了光引发剂的化学性质和照射条件。主要结果是，使用 2-甲基-4'-(甲硫基)-2-吗啉代-苯丙酮作为光引发剂，可以同时聚合并将所得整体结构锚定到 PDMS 通道上。整料的形态显示出由均匀的结节（135 +/- 30 nm）和小孔（10-200 nm）组成的致密结构。所获得的高比表面积（66 m(2)/g）和足够的渗透性（14.35 x 10(-14) m(2)）使得该整体材料对于预浓缩特别有意义。这种自由基介导的方法为 PDMS 微系统中的预富集和电泳分离开辟了新的前景。 (C) 2015 Elsevier Ltd. 保留所有权利。
We report here a one-pot approach to achieve, for the first time, the simultaneous synthesis/anchorage of polymer monoliths in native PDMS channels. Monoliths consisting of ethylene glycol methacrylate phosphate (EGMP) and N,N'-methylene-bis-acrylamide (BAA) were synthesized within PDMS microchips through a photo-driven process. The EGMP monomer has never been employed for this purpose. To achieve this method, both the chemical nature of the photoinitiator and irradiation conditions were investigated. The main result was that the use of 2-methyl-4'-(methylthio)-2-morpholino-propiophenone, as photoinitiator, allowed simultaneous polymerization and anchorage of the resulting monolithic structure onto the PDMS channel. Morphology of the monolith revealed a compact structure composed of uniform nodules (135 +/- 30 nm) and small pores (10-200 nm). The high specific surface area (66 m(2)/g) and the sufficient permeability (14.35 x 10(-14) m(2)) obtained make the monolith particularly interesting for preconcentration. Such free radical-mediated method open new perspectives for preconcentration and electrophoretic separation in PDMS microsystems. (C) 2015 Elsevier Ltd. All rights reserved.