Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239.
Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239.
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寄生虫可能会从感染了 SIVmac239 的免疫功能低下的北方猪尾猕猴（Macaca leonina）中排出。
DOI：
10.24272/j.issn.2095-8137.2018.015
复制
发表时间：
2018-01-18
影响因子：
4.9
通讯作者：
Zheng YT
中科院分区：
文献类型：
--
作者：
Song TZ;Zhang MX;Xia YJ;Xiao Y;Pang W;Zheng YT
寄生虫可增加免疫功能低下的人类免疫缺陷病毒（HIV）患者的感染率和致病性。然而，体外研究和流行病学调查也表明，寄生虫可能会逃脱免疫功能低下的主机在艾滋病毒感染。由于缺乏来自动物实验的直接证据，寄生虫感染对免疫受损宿主的影响仍不清楚。在这里，我们检测了14种不同的寄生虫在6个北方猪尾猕猴（NPMs）之前或在50周的猿猴免疫缺陷病毒（SIV）感染ELISA。NPM在病毒注射前均携带寄生虫。在病毒注射后第50周，寄生虫检测结果为阴性的个体（即，08247和08287）被表征为寄生虫退出（PE）组，而其他个体（即，09203、09211、10205和10225），其特征为寄生虫残留（PR）组。与PR组相比，PE组NPM的病毒载量较高，CD 4 + T细胞计数较低，CD 4/CD 8比值较低。此外，PE组具有较高的CD 4+和CD 8 + T细胞的免疫活化和免疫耗竭。病理学观察显示PE组肝脏、盲肠、结肠、脾脏及肠系膜淋巴结损伤较PE组明显。这项研究表明，PE组的免疫力受损更严重，强烈表明寄生虫可能会离开免疫功能低下的宿主。
Parasites can increase infection rates and pathogenicity in immunocompromised human immunodeficiency virus (HIV) patients. However, in vitro studies and epidemiological investigations also suggest that parasites might escape immunocompromised hosts during HIV infection. Due to the lack of direct evidence from animal experiments, the effects of parasitic infections on immunocompromised hosts remain unclear. Here, we detected 14 different parasites in six northern pig-tailed macaques (NPMs) before or at the 50th week of simian immunodeficiency virus (SIV) infection by ELISA. The NPMs all carried parasites before viral injection. At the 50th week after viral injection, the individuals with negative results in parasitic detection (i.e., 08247 and 08287) were characterized as the Parasites Exit (PE) group, with the other individuals (i.e., 09203, 09211, 10205, and 10225) characterized as the Parasites Remain (PR) group. Compared with the PR group, the NPMs in the PE group showed higher viral loads, lower CD4+ T cells counts, and lower CD4/CD8 rates. Additionally, the PE group had higher immune activation and immune exhaustion of both CD4+ and CD8+ T cells. Pathological observation showed greater injury to the liver, cecum, colon, spleen, and mesenteric lymph nodes in the PE group. This study showed more seriously compromised immunity in the PE group, strongly indicating that parasites might exit an immunocompromised host.
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DOI：
10.4269/ajtmh.1997.56.515
发表时间：
1997-05-01
影响因子：
3.3
作者：
Karanja, DMS;Colley, DG;Secor, WE
通讯作者：
Secor, WE
影响因子：
3.6
作者：
Palladino, Claudia;Climent, Francisco J.;Angeles Munoz-Fernandez, Ma
通讯作者：
Angeles Munoz-Fernandez, Ma
DOI：
10.1016/s0167-5699(99)01499-1
发表时间：
1999-11-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
Bentwich, Z;Kalinkovich, A;Beyers, AD
通讯作者：
Beyers, AD
DOI：
10.1016/0950-3528(90)90042-f
发表时间：
1990-03-01
期刊：
BAILLIERES CLINICAL GASTROENTEROLOGY
影响因子：
--
作者：
GRIFFIN, GE
通讯作者：
GRIFFIN, GE
影响因子：
1.8
作者：
O'Bryan TA;Okulicz JF;Bradley WP;Ganesan A;Wang X;Agan BK
通讯作者：
Agan BK