Interaction of genetic risk and adoptive parent communication deviance: longitudinal prediction of adoptee psychiatric disorders
Interaction of genetic risk and adoptive parent communication deviance: longitudinal prediction of adoptee psychiatric disorders
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DOI：
10.1017/s0033291704002661
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发表时间：
2004-11
影响因子：
6.9
通讯作者：
K. Wahlberg;L. Wynne;H. Hakko;K. Läksy;J. Moring;J. Miettunen;P. Tienari
中科院分区：
文献类型：
--
作者：
K. Wahlberg;L. Wynne;H. Hakko;K. Läksy;J. Moring;J. Miettunen;P. Tienari
背景在芬兰精神分裂症家族研究中，被收养者的思维障碍被证明是精神分裂症谱系障碍的遗传易感性和收养抚养父母沟通模式的联合效应。然而，纵向预测的临床精神疾病的被收养者还没有报道。法从芬兰精神分裂症收养研究的总样本中选择在初始评估时没有DSM-III-R障碍的患者（n=109）（中位年龄18岁）。他们被定义为高与低遗传风险的基础上，他们的生物学，收养了母亲的一生诊断-精神分裂症谱系障碍与非谱系障碍。在最初的评估中，养父母被独立地评估，从录音罗夏协议得分为表现出高或低的沟通偏差（CD），一个复合指数的沟通模式，分散和迷惑听众。患者在中位间隔14年后被独立重新诊断，并从国家登记处随访7年。结果遗传倾向（G）和CD的养父母（E），每一个单独的主要影响，预测显着的精神障碍的被收养人作为成年人。然而，当G、E及其联合交互作用进入同一逻辑斯蒂模型时，只有交互作用显著。样本包括7名患有精神分裂症谱系障碍的被收养者，但预测他们的单独分析并不显着。结论精神分裂症谱系障碍的遗传易感性和收养家庭养育变量相互作用，纵向和显着预测广义的被收养者精神障碍。
Background. In the Finnish Adoptive Family Study of Schizophrenia, adoptee thinking disorders have been shown to be a joint effect of genetic liability for schizophrenia spectrum disorders and adoptive rearing-parent communication patterns. However, longitudinal predictions of clinical psychiatric disorders of the adoptees have not been reported. Method. Adoptees (n=109) who had no DSM-III-R disorder at initial assessment (median age 18 years) were selected from the total sample of the Finnish Adoption Study of Schizophrenia. They were defined as at high versus low genetic risk based upon the lifetime diagnoses of their biological, adopting-away mothers – schizophrenia spectrum disorder versus no spectrum disorder. At initial assessment, adoptive rearing parents were independently evaluated from tape-recorded Rorschach protocols scored as manifesting either high or low Communication Deviance (CD), a composite index of communication patterns that distract and befuddle listeners. Adoptees were independently re-diagnosed after a median interval of 14 years and followed-up from national registers for an additional 7 years. Results. The main effects of genetic liability (G) and CD of the adoptive parents (E), each taken separately, predicted significantly for psychiatric disorders of the adoptees as adults. However, when G, E, and their joint interaction effect were entered into the same logistic model, only the interaction effect was significant. The sample included seven adoptees with schizophrenia spectrum disorders, but a separate analysis to predict them was non-significant. Conclusion. Genetic liability for schizophrenia spectrum disorder and an adoptive family rearing variable interact, predicting longitudinally and significantly to broadly defined adoptee psychiatric disorder.